Body temperature influences ethanol and ethanol/pentobarbital lethality in mice

Deborah (Deb) Finn, Peter J. Syapin, Marina Bejanian, Brenda L. Jones, Ronald L. Alkana

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effect of body temperature on ethanol (ETOH) or ethanol plus pentobarbital (ETOH/PB) lethality was investigated in C57BL/6J mice. Decreasing ambient temperatures from 35-20°C, decreased rectal temperatures from 38-20°C and increased 8-hour survival from 0-93% for ETOH-treated and from 0-100% for ETOH/PB-treated mice. ETOH and ETOH/PB animals with no hypothermia (body temperatures = 38°C) had the highest lethality. Those with body temperatures between 30-32°C had the highest 24-hour survival. These results suggest that controlled hypothermia may be useful in reducing lethality from ethanol or ethanol/combination overdoses.

Original languageEnglish (US)
Pages (from-to)39-41
Number of pages3
JournalAlcohol
Volume8
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Pentobarbital
Body Temperature
Ethanol
Hypothermia
Temperature
animal
Inbred C57BL Mouse
Animals

Keywords

  • Body temperature
  • Ethanol
  • Lethality
  • Mice
  • Pentobarbital

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Body temperature influences ethanol and ethanol/pentobarbital lethality in mice. / Finn, Deborah (Deb); Syapin, Peter J.; Bejanian, Marina; Jones, Brenda L.; Alkana, Ronald L.

In: Alcohol, Vol. 8, No. 1, 1991, p. 39-41.

Research output: Contribution to journalArticle

Finn, Deborah (Deb) ; Syapin, Peter J. ; Bejanian, Marina ; Jones, Brenda L. ; Alkana, Ronald L. / Body temperature influences ethanol and ethanol/pentobarbital lethality in mice. In: Alcohol. 1991 ; Vol. 8, No. 1. pp. 39-41.
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