Body temperature influences ethanol and ethanol/pentobarbital lethality in mice

Deborah A. Finn, Peter J. Syapin, Marina Bejanian, Brenda L. Jones, Ronald L. Alkana

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The effect of body temperature on ethanol (ETOH) or ethanol plus pentobarbital (ETOH/PB) lethality was investigated in C57BL/6J mice. Decreasing ambient temperatures from 35-20°C, decreased rectal temperatures from 38-20°C and increased 8-hour survival from 0-93% for ETOH-treated and from 0-100% for ETOH/PB-treated mice. ETOH and ETOH/PB animals with no hypothermia (body temperatures = 38°C) had the highest lethality. Those with body temperatures between 30-32°C had the highest 24-hour survival. These results suggest that controlled hypothermia may be useful in reducing lethality from ethanol or ethanol/combination overdoses.

Original languageEnglish (US)
Pages (from-to)39-41
Number of pages3
JournalAlcohol
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1991

Keywords

  • Body temperature
  • Ethanol
  • Lethality
  • Mice
  • Pentobarbital

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

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