Body temperature influences ethanol and ethanol/pentobarbital lethality in mice

Deborah A. Finn; Peter J. Syapin; Marina Bejanian; Brenda L. Jones; Ronald L. Alkana

doi:10.1016/0741-8329(91)91232-Q

Body temperature influences ethanol and ethanol/pentobarbital lethality in mice

Deborah A. Finn, Peter J. Syapin, Marina Bejanian, Brenda L. Jones, Ronald L. Alkana

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effect of body temperature on ethanol (ETOH) or ethanol plus pentobarbital (ETOH/PB) lethality was investigated in C57BL/6J mice. Decreasing ambient temperatures from 35-20°C, decreased rectal temperatures from 38-20°C and increased 8-hour survival from 0-93% for ETOH-treated and from 0-100% for ETOH/PB-treated mice. ETOH and ETOH/PB animals with no hypothermia (body temperatures = 38°C) had the highest lethality. Those with body temperatures between 30-32°C had the highest 24-hour survival. These results suggest that controlled hypothermia may be useful in reducing lethality from ethanol or ethanol/combination overdoses.

Original language	English (US)
Pages (from-to)	39-41
Number of pages	3
Journal	Alcohol
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/0741-8329(91)91232-Q
State	Published - 1991
Externally published	Yes

Keywords

Body temperature
Ethanol
Lethality
Mice
Pentobarbital

ASJC Scopus subject areas

Health(social science)
Biochemistry
Toxicology
Neurology
Behavioral Neuroscience

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10.1016/0741-8329(91)91232-Q

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@article{ce7e3b5cf25a4433b57f7e565f7e0604,

title = "Body temperature influences ethanol and ethanol/pentobarbital lethality in mice",

abstract = "The effect of body temperature on ethanol (ETOH) or ethanol plus pentobarbital (ETOH/PB) lethality was investigated in C57BL/6J mice. Decreasing ambient temperatures from 35-20°C, decreased rectal temperatures from 38-20°C and increased 8-hour survival from 0-93% for ETOH-treated and from 0-100% for ETOH/PB-treated mice. ETOH and ETOH/PB animals with no hypothermia (body temperatures = 38°C) had the highest lethality. Those with body temperatures between 30-32°C had the highest 24-hour survival. These results suggest that controlled hypothermia may be useful in reducing lethality from ethanol or ethanol/combination overdoses.",

keywords = "Body temperature, Ethanol, Lethality, Mice, Pentobarbital",

author = "Finn, {Deborah A.} and Syapin, {Peter J.} and Marina Bejanian and Jones, {Brenda L.} and Alkana, {Ronald L.}",

note = "Funding Information: This work was supported by the United States Public Health Service Research Grant RO1 AA05234 from the National Institute on Alcohol Abuse and Alcoholism, ADAMHA. The authors thank Guntwin Galleisky for technical assistance, Leigh Kobayashi for figure preparation and Shaunna Thomas for manuscript preparation.",

year = "1991",

doi = "10.1016/0741-8329(91)91232-Q",

language = "English (US)",

volume = "8",

pages = "39--41",

journal = "Alcohol",

issn = "0741-8329",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Body temperature influences ethanol and ethanol/pentobarbital lethality in mice

AU - Finn, Deborah A.

AU - Syapin, Peter J.

AU - Bejanian, Marina

AU - Jones, Brenda L.

AU - Alkana, Ronald L.

N1 - Funding Information: This work was supported by the United States Public Health Service Research Grant RO1 AA05234 from the National Institute on Alcohol Abuse and Alcoholism, ADAMHA. The authors thank Guntwin Galleisky for technical assistance, Leigh Kobayashi for figure preparation and Shaunna Thomas for manuscript preparation.

PY - 1991

Y1 - 1991

N2 - The effect of body temperature on ethanol (ETOH) or ethanol plus pentobarbital (ETOH/PB) lethality was investigated in C57BL/6J mice. Decreasing ambient temperatures from 35-20°C, decreased rectal temperatures from 38-20°C and increased 8-hour survival from 0-93% for ETOH-treated and from 0-100% for ETOH/PB-treated mice. ETOH and ETOH/PB animals with no hypothermia (body temperatures = 38°C) had the highest lethality. Those with body temperatures between 30-32°C had the highest 24-hour survival. These results suggest that controlled hypothermia may be useful in reducing lethality from ethanol or ethanol/combination overdoses.

AB - The effect of body temperature on ethanol (ETOH) or ethanol plus pentobarbital (ETOH/PB) lethality was investigated in C57BL/6J mice. Decreasing ambient temperatures from 35-20°C, decreased rectal temperatures from 38-20°C and increased 8-hour survival from 0-93% for ETOH-treated and from 0-100% for ETOH/PB-treated mice. ETOH and ETOH/PB animals with no hypothermia (body temperatures = 38°C) had the highest lethality. Those with body temperatures between 30-32°C had the highest 24-hour survival. These results suggest that controlled hypothermia may be useful in reducing lethality from ethanol or ethanol/combination overdoses.

KW - Body temperature

KW - Ethanol

KW - Lethality

KW - Mice

KW - Pentobarbital

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U2 - 10.1016/0741-8329(91)91232-Q

DO - 10.1016/0741-8329(91)91232-Q

M3 - Article

C2 - 2006984

AN - SCOPUS:0026034378

SN - 0741-8329

VL - 8

SP - 39

EP - 41

JO - Alcohol

JF - Alcohol

IS - 1

ER -

Body temperature influences ethanol and ethanol/pentobarbital lethality in mice

Abstract

Keywords

ASJC Scopus subject areas

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