Body temperature and ethanol pharmacokinetics in temperature-challenged mice

M. Bejanian, D. A. Finn, P. J. Syapin, R. L. Alkana

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The relationships between ambient temperature, body temperature, ethanol pharmacokinetics and behavioral sensitivity to ethanol were examined in C57BL/6 mice. Mice were injected intraperitoneally with 3.6 or 2.0 g/kg ethanol. Exposure to increasing ambient temperatures of 4-34°C immediately after ethanol injection resulted in a significant increase in body temperature, ethanol elimination rate and brain:blood ethanol concentration ratios in 3.6 g/kg ethanol-injected mice, but not in mice injected with 2.0 g/kg ethanol. As the mean body temperature increased from 26.0 to 38.2°C in the 3.6 g/kg mice, there was a 50% increase in ethanol elimination rate. Delayed (30 min) exposure to increasing ambient temperatures following injection of 3.6 g/kg ethanol resulted in a significant increase in ethanol elimination rate, a marked increase in the duration of loss of righting reflex and a decrease in ethanol concentration at the regain of righting reflex. The results indicate that temperature-induced changes in the absorption, distribution and elimination of ethanol do not appear to mediate the effects of temperature on behavioral sensitivity to ethanol in C57 mice.

Original languageEnglish (US)
Pages (from-to)331-337
Number of pages7
JournalAlcohol
Volume7
Issue number4
DOIs
StatePublished - Jan 1 1990

Keywords

  • Alcohol-ethyl
  • Body temperature
  • Ethanol elimination rate
  • Ethanol pharmacokinetics
  • Ethanol sensitivity
  • Temperature challenge

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

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