Board-invited review: Estrogen and progesterone signaling: Genomic and nongenomic actions in domestic ruminants

F. Stormshak, Cecily Bishop

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    Abstract

    Progesterone and estrogens play key roles in regulating various physiological phenomena related to normal growth, development, and reproduction of domestic animals. This review focuses on the mechanisms by which progesterone and estrogens regulate the reproductive processes in these animals. The majority of research on the actions of progesterone and estrogens on the reproductive systems of cattle, sheep, and pigs has been genomic in nature and represents attempts to better understand how these steroids regulate gene expression. Results of recent research suggest that progesterone and estrogens can alter target cell responses nongenomically via membrane receptors. The characteristics of membrane receptors for progesterone and estrogen in various cell types are described and the intracellular signal pathways defined. Estrogens acting via membrane receptors can suppress LH secretion by gonadotropes and stimulate rapid increases in uterine blood flow. Progesterone acting via a membrane receptor has been shown to inhibit binding of oxytocin to oxytocin receptors in isolated endometrial plasma membranes and stimulate capacitation of spermatozoa. Results of research suggest that progesterone and estrogens can act nongenomically to alter target cell responses in domestic animals. The biological implications of this mode of action in these animals are discussed.

    Original languageEnglish (US)
    Pages (from-to)299-315
    Number of pages17
    JournalJournal of Animal Science
    Volume86
    Issue number2
    DOIs
    StatePublished - Feb 2008

    Fingerprint

    Ruminants
    estrogens
    Progesterone
    ruminants
    progesterone
    Estrogens
    genomics
    Membranes
    Domestic Animals
    domestic animals
    receptors
    Research
    Sperm Capacitation
    Physiological Phenomena
    Oxytocin Receptors
    sperm capacitation
    oxytocin
    reproductive system
    cells
    Oxytocin

    Keywords

    • Estradiol-17β
    • Luteinizing hormone
    • Membrane receptor
    • Oxytocin
    • Progesterone
    • Uterus

    ASJC Scopus subject areas

    • Animal Science and Zoology

    Cite this

    Board-invited review : Estrogen and progesterone signaling: Genomic and nongenomic actions in domestic ruminants. / Stormshak, F.; Bishop, Cecily.

    In: Journal of Animal Science, Vol. 86, No. 2, 02.2008, p. 299-315.

    Research output: Contribution to journalArticle

    @article{7199ffb1cee24243a952787b63899570,
    title = "Board-invited review: Estrogen and progesterone signaling: Genomic and nongenomic actions in domestic ruminants",
    abstract = "Progesterone and estrogens play key roles in regulating various physiological phenomena related to normal growth, development, and reproduction of domestic animals. This review focuses on the mechanisms by which progesterone and estrogens regulate the reproductive processes in these animals. The majority of research on the actions of progesterone and estrogens on the reproductive systems of cattle, sheep, and pigs has been genomic in nature and represents attempts to better understand how these steroids regulate gene expression. Results of recent research suggest that progesterone and estrogens can alter target cell responses nongenomically via membrane receptors. The characteristics of membrane receptors for progesterone and estrogen in various cell types are described and the intracellular signal pathways defined. Estrogens acting via membrane receptors can suppress LH secretion by gonadotropes and stimulate rapid increases in uterine blood flow. Progesterone acting via a membrane receptor has been shown to inhibit binding of oxytocin to oxytocin receptors in isolated endometrial plasma membranes and stimulate capacitation of spermatozoa. Results of research suggest that progesterone and estrogens can act nongenomically to alter target cell responses in domestic animals. The biological implications of this mode of action in these animals are discussed.",
    keywords = "Estradiol-17β, Luteinizing hormone, Membrane receptor, Oxytocin, Progesterone, Uterus",
    author = "F. Stormshak and Cecily Bishop",
    year = "2008",
    month = "2",
    doi = "10.2527/jas.2007-0489",
    language = "English (US)",
    volume = "86",
    pages = "299--315",
    journal = "Journal of Animal Science",
    issn = "0021-8812",
    publisher = "American Society of Animal Science",
    number = "2",

    }

    TY - JOUR

    T1 - Board-invited review

    T2 - Estrogen and progesterone signaling: Genomic and nongenomic actions in domestic ruminants

    AU - Stormshak, F.

    AU - Bishop, Cecily

    PY - 2008/2

    Y1 - 2008/2

    N2 - Progesterone and estrogens play key roles in regulating various physiological phenomena related to normal growth, development, and reproduction of domestic animals. This review focuses on the mechanisms by which progesterone and estrogens regulate the reproductive processes in these animals. The majority of research on the actions of progesterone and estrogens on the reproductive systems of cattle, sheep, and pigs has been genomic in nature and represents attempts to better understand how these steroids regulate gene expression. Results of recent research suggest that progesterone and estrogens can alter target cell responses nongenomically via membrane receptors. The characteristics of membrane receptors for progesterone and estrogen in various cell types are described and the intracellular signal pathways defined. Estrogens acting via membrane receptors can suppress LH secretion by gonadotropes and stimulate rapid increases in uterine blood flow. Progesterone acting via a membrane receptor has been shown to inhibit binding of oxytocin to oxytocin receptors in isolated endometrial plasma membranes and stimulate capacitation of spermatozoa. Results of research suggest that progesterone and estrogens can act nongenomically to alter target cell responses in domestic animals. The biological implications of this mode of action in these animals are discussed.

    AB - Progesterone and estrogens play key roles in regulating various physiological phenomena related to normal growth, development, and reproduction of domestic animals. This review focuses on the mechanisms by which progesterone and estrogens regulate the reproductive processes in these animals. The majority of research on the actions of progesterone and estrogens on the reproductive systems of cattle, sheep, and pigs has been genomic in nature and represents attempts to better understand how these steroids regulate gene expression. Results of recent research suggest that progesterone and estrogens can alter target cell responses nongenomically via membrane receptors. The characteristics of membrane receptors for progesterone and estrogen in various cell types are described and the intracellular signal pathways defined. Estrogens acting via membrane receptors can suppress LH secretion by gonadotropes and stimulate rapid increases in uterine blood flow. Progesterone acting via a membrane receptor has been shown to inhibit binding of oxytocin to oxytocin receptors in isolated endometrial plasma membranes and stimulate capacitation of spermatozoa. Results of research suggest that progesterone and estrogens can act nongenomically to alter target cell responses in domestic animals. The biological implications of this mode of action in these animals are discussed.

    KW - Estradiol-17β

    KW - Luteinizing hormone

    KW - Membrane receptor

    KW - Oxytocin

    KW - Progesterone

    KW - Uterus

    UR - http://www.scopus.com/inward/record.url?scp=38949118253&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=38949118253&partnerID=8YFLogxK

    U2 - 10.2527/jas.2007-0489

    DO - 10.2527/jas.2007-0489

    M3 - Article

    C2 - 17965328

    AN - SCOPUS:38949118253

    VL - 86

    SP - 299

    EP - 315

    JO - Journal of Animal Science

    JF - Journal of Animal Science

    SN - 0021-8812

    IS - 2

    ER -