Blood pressure and mesenteric resistance arterial function after spaceflight

Daniel C. Hatton, Qi Yue, Justin Chapman, Hong Xue, Jacqueline Dierickx, Chantal Roullet, Sarah Coste, Jean Baptiste Roullet, David A. McCarron

    Research output: Contribution to journalArticlepeer-review

    16 Scopus citations


    Ground studies indicate that spaceflight may diminish vascular contraction. To examine that possibility, vascular function was measured in spontaneously hypertensive rats immediately after an 18-day shuttle flight. Isolated mesenteric resistance arterial responses to cumulative additions of norepinephrine, acetylcholine, and sodium nitroprusside were measured using wire myography within 17 h of landing. After flight, maximal contraction to norepinephrine was attenuated (P < 0.001) as was relaxation to acetylcholine (P < 0.001) and sodium nitroprusside (P < 0.05). At high concentrations, acetylcholine caused vascular contraction in vessels from flight animals but not in vessels from vivarium control animals (P < 0.05). The results are consistent with data from ground studies and indicate that spaceflight causes both endothelial-dependent and endothelial-independent alterations in vascular function. The resulting decrement in vascular function may contribute to orthostatic intolerance after spaceflight.

    Original languageEnglish (US)
    Pages (from-to)13-17
    Number of pages5
    JournalJournal of Applied Physiology
    Issue number1
    StatePublished - 2002


    • Microgravity
    • Spontaneously hypertensive rats
    • Vascular contraction
    • Vascular relaxation

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)


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