Blood pressure and mesenteric resistance arterial function after spaceflight

Daniel C. Hatton, Qi Yue, Justin Chapman, Hong Xue, Jacqueline Dierickx, Chantal Roullet, Sarah Coste, Jean Baptiste Roullet, David A. McCarron

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Ground studies indicate that spaceflight may diminish vascular contraction. To examine that possibility, vascular function was measured in spontaneously hypertensive rats immediately after an 18-day shuttle flight. Isolated mesenteric resistance arterial responses to cumulative additions of norepinephrine, acetylcholine, and sodium nitroprusside were measured using wire myography within 17 h of landing. After flight, maximal contraction to norepinephrine was attenuated (P < 0.001) as was relaxation to acetylcholine (P < 0.001) and sodium nitroprusside (P < 0.05). At high concentrations, acetylcholine caused vascular contraction in vessels from flight animals but not in vessels from vivarium control animals (P < 0.05). The results are consistent with data from ground studies and indicate that spaceflight causes both endothelial-dependent and endothelial-independent alterations in vascular function. The resulting decrement in vascular function may contribute to orthostatic intolerance after spaceflight.

Original languageEnglish (US)
Pages (from-to)13-17
Number of pages5
JournalJournal of Applied Physiology
Volume92
Issue number1
DOIs
StatePublished - Jan 1 2002

Keywords

  • Microgravity
  • Spontaneously hypertensive rats
  • Vascular contraction
  • Vascular relaxation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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  • Cite this

    Hatton, D. C., Yue, Q., Chapman, J., Xue, H., Dierickx, J., Roullet, C., Coste, S., Roullet, J. B., & McCarron, D. A. (2002). Blood pressure and mesenteric resistance arterial function after spaceflight. Journal of Applied Physiology, 92(1), 13-17. https://doi.org/10.1152/jappl.2002.92.1.13