Blood pressure and mesenteric resistance arterial function after spaceflight

Daniel C. Hatton, Qi Yue, Justin Chapman, Hong Xue, Jacqueline Dierickx, Chantal Roullet, Sarah Coste, Jean-Baptiste Roullet, David A. McCarron

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Ground studies indicate that spaceflight may diminish vascular contraction. To examine that possibility, vascular function was measured in spontaneously hypertensive rats immediately after an 18-day shuttle flight. Isolated mesenteric resistance arterial responses to cumulative additions of norepinephrine, acetylcholine, and sodium nitroprusside were measured using wire myography within 17 h of landing. After flight, maximal contraction to norepinephrine was attenuated (P <0.001) as was relaxation to acetylcholine (P <0.001) and sodium nitroprusside (P <0.05). At high concentrations, acetylcholine caused vascular contraction in vessels from flight animals but not in vessels from vivarium control animals (P <0.05). The results are consistent with data from ground studies and indicate that spaceflight causes both endothelial-dependent and endothelial-independent alterations in vascular function. The resulting decrement in vascular function may contribute to orthostatic intolerance after spaceflight.

Original languageEnglish (US)
Pages (from-to)13-17
Number of pages5
JournalJournal of Applied Physiology
Volume92
Issue number1
StatePublished - 2002

Fingerprint

Space Flight
Blood Vessels
Blood Pressure
Acetylcholine
Nitroprusside
Animal Flight
Norepinephrine
Myography
Orthostatic Intolerance
Inbred SHR Rats

Keywords

  • Microgravity
  • Spontaneously hypertensive rats
  • Vascular contraction
  • Vascular relaxation

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hatton, D. C., Yue, Q., Chapman, J., Xue, H., Dierickx, J., Roullet, C., ... McCarron, D. A. (2002). Blood pressure and mesenteric resistance arterial function after spaceflight. Journal of Applied Physiology, 92(1), 13-17.

Blood pressure and mesenteric resistance arterial function after spaceflight. / Hatton, Daniel C.; Yue, Qi; Chapman, Justin; Xue, Hong; Dierickx, Jacqueline; Roullet, Chantal; Coste, Sarah; Roullet, Jean-Baptiste; McCarron, David A.

In: Journal of Applied Physiology, Vol. 92, No. 1, 2002, p. 13-17.

Research output: Contribution to journalArticle

Hatton, DC, Yue, Q, Chapman, J, Xue, H, Dierickx, J, Roullet, C, Coste, S, Roullet, J-B & McCarron, DA 2002, 'Blood pressure and mesenteric resistance arterial function after spaceflight', Journal of Applied Physiology, vol. 92, no. 1, pp. 13-17.
Hatton DC, Yue Q, Chapman J, Xue H, Dierickx J, Roullet C et al. Blood pressure and mesenteric resistance arterial function after spaceflight. Journal of Applied Physiology. 2002;92(1):13-17.
Hatton, Daniel C. ; Yue, Qi ; Chapman, Justin ; Xue, Hong ; Dierickx, Jacqueline ; Roullet, Chantal ; Coste, Sarah ; Roullet, Jean-Baptiste ; McCarron, David A. / Blood pressure and mesenteric resistance arterial function after spaceflight. In: Journal of Applied Physiology. 2002 ; Vol. 92, No. 1. pp. 13-17.
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