Blood component supplementation during massive transfusion of as-1 red cells in trauma patients

Paul D. Faringer, Richard J. Mullins, Roderick L. Johnson, Donald D. Trunkey

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Coagulation component transfusions in trauma patients given more than 10 units of AS-1 red cells during the first 24 hours after injury were studied. Serial coagulation tests were obtained to direct component therapy. Coagulopathy developed in more than 70% of patients. Patients with blunt or penetrating trauma had similar coagulation abnormalities during massive transfusions. More than 40% of patients with either exsanguinating hemorrhage from penetrating trauma or blunt trauma with associated brain injuries had abnormal coagulation tests on admission. In contrast, patients with blunt trauma, but without brain injury, did not have coagulopathy on admission. Patients received an average of 25 units (range, 10-77) of AS-1 red cells and were exposed to an average of 80 (range, 11-252) donors. Exsanguination and brain injuries primarily caused death in 57%. Abnormal coagulation tests will be frequent and profound during a massive transfusion with AS-1 red cells. Serial coagulation testing is recommended.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalJournal of Trauma - Injury, Infection and Critical Care
Issue number4
StatePublished - Apr 1993
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine


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