Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat

Marianne Juhler, David I. Barry, Halina Offner, Gregory Konat, Leif Klinken, Olaf B. Paulson

Research output: Contribution to journalArticle

107 Scopus citations

Abstract

Experimental allergic encephalomyelitis (EAE) was induced in young male Lewis rats. Blood-brain barrier permeability to radiotracers of different molecular sizes was studied at intervals after induction using a tissue sampling technique. The results were correlated to the clinical picture and to the histological appearance of the central nervous system. Significant increase in blood-brain barrier permeability to small molecules was found to precede clinical symtoms by one day in the lumbar spinal cord and to coincide with the onset of clinical disease in other regions. In all regions, increased blood-brain barrier permeability preceded the occurrence of histological lesions (perivascular cellular infiltrates). No permeability increase to large molecules could be demonstrated.

Original languageEnglish (US)
Pages (from-to)347-355
Number of pages9
JournalBrain research
Volume302
Issue number2
DOIs
StatePublished - Jun 8 1984

Keywords

  • blood-brain barrier (BBB)
  • experimental allergic encephalomyelitis (EAE)
  • focal inflammation of the central nervous system (perivascular)
  • restricted diffusion
  • time course study of EAE
  • tissue sampling method

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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