Blockade of opioid receptors in anterior cingulate cortex disrupts ethanol-seeking behavior in mice

Christina M. Gremel, Emily A. Young, Christopher L. Cunningham

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The anterior cingulate cortex (ACC) and opioid receptors have been suggested to play a role in attributing incentive motivational properties to drug-related cues. We examined whether blockade of ACC opioid receptors would reduce cue-induced ethanol-seeking behavior in mice. We show that intra-ACC opioid receptor blockade disrupted expression of an ethanol-induced conditioned place preference, suggesting that endogenous opioid modulation in the ACC may be critical for maintaining the cue's conditioned rewarding effects.

Original languageEnglish (US)
Pages (from-to)358-362
Number of pages5
JournalBehavioural Brain Research
Volume219
Issue number2
DOIs
StatePublished - Jun 1 2011

Keywords

  • Anterior cingulate cortex
  • Conditioned place preference
  • Cue-induced drug seeking
  • Ethanol
  • Incentive motivation
  • Opioid receptors

ASJC Scopus subject areas

  • Behavioral Neuroscience

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