Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors

E. Traer; R. MacKenzie; J. Snead; A. Agarwal; A. M. Eiring; T. O'Hare; B. J. Druker; M. W. Deininger

doi:10.1038/leu.2011.325

Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors

E. Traer, R. MacKenzie, J. Snead, A. Agarwal, A. M. Eiring, T. O'Hare, B. J. Druker, M. W. Deininger

Knight Cancer Institute

Research output: Contribution to journal › Letter › peer-review

91 Scopus citations

Original language	English (US)
Pages (from-to)	1140-1143
Number of pages	4
Journal	Leukemia
Volume	26
Issue number	5
DOIs	https://doi.org/10.1038/leu.2011.325
State	Published - May 2012

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1038/leu.2011.325

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title = "Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors",

author = "E. Traer and R. MacKenzie and J. Snead and A. Agarwal and Eiring, {A. M.} and T. O'Hare and Druker, {B. J.} and Deininger, {M. W.}",

note = "Funding Information: We thank Chris Koontz, Sarah Bowden and Suzanne Wickens for administrative support. This study was supported by NHLBI grant HL082978-01 (MWD) and the Leukemia and Lymphoma Society (MWD). ET is supported by T32 Molecular Hematology Training Grant HL007781-18. Funding Information: This study was supported by the Hannelore-Munke Fellowship and grant #109686 by the Deutsche Krebshilfe awarded to FD; HiLF grant from Hannover Medical School awarded to FT; association {\textquoteleft}Laurette Fugain{\textquoteright} (OAB and FD); grant {\textquoteleft}Direction de la recherche clinique AP-HP (PHRC MDS-04){\textquoteright} and INCa translational research 2008 awarded to FM; grant No. DJCLS R 10/22 from the Deutsche-Jos{\'e}-Carreras Leuk{\"a}mie-Stiftung e.V.; grant No. 109003 from the Deutsche Krebshilfe e.V; and grant No. M 47.1 from the H. W. & J. Hector Stiftung. We thank the investigators of the German myelodysplastic study group and the Groupe Francophone des My{\'e}lodysplasies (Dr B Slama, Avignon; Dr Gardembas, Angers; Dr Dib, Angers; Dr Rose, Lille; Dr Cheze, Caen; Dr Ame, Strasbourg; Dr Gyan, Tours) for including patients, and Martin Wichmann, Kerstin G{\"o}hrlich, Lamya Slama, Gaelle Herledan and Julien Brard for technical assistance.",

year = "2012",

month = may,

doi = "10.1038/leu.2011.325",

language = "English (US)",

volume = "26",

pages = "1140--1143",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "5",

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T1 - Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors

AU - Traer, E.

AU - MacKenzie, R.

AU - Snead, J.

AU - Agarwal, A.

AU - Eiring, A. M.

AU - O'Hare, T.

AU - Druker, B. J.

AU - Deininger, M. W.

N1 - Funding Information: We thank Chris Koontz, Sarah Bowden and Suzanne Wickens for administrative support. This study was supported by NHLBI grant HL082978-01 (MWD) and the Leukemia and Lymphoma Society (MWD). ET is supported by T32 Molecular Hematology Training Grant HL007781-18. Funding Information: This study was supported by the Hannelore-Munke Fellowship and grant #109686 by the Deutsche Krebshilfe awarded to FD; HiLF grant from Hannover Medical School awarded to FT; association ‘Laurette Fugain’ (OAB and FD); grant ‘Direction de la recherche clinique AP-HP (PHRC MDS-04)’ and INCa translational research 2008 awarded to FM; grant No. DJCLS R 10/22 from the Deutsche-José-Carreras Leukämie-Stiftung e.V.; grant No. 109003 from the Deutsche Krebshilfe e.V; and grant No. M 47.1 from the H. W. & J. Hector Stiftung. We thank the investigators of the German myelodysplastic study group and the Groupe Francophone des Myélodysplasies (Dr B Slama, Avignon; Dr Gardembas, Angers; Dr Dib, Angers; Dr Rose, Lille; Dr Cheze, Caen; Dr Ame, Strasbourg; Dr Gyan, Tours) for including patients, and Martin Wichmann, Kerstin Göhrlich, Lamya Slama, Gaelle Herledan and Julien Brard for technical assistance.

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Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors

ASJC Scopus subject areas

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