Bleomycin-mediated DNA cross-links are dependent on closed-circular molecules with superhelical turns

R. S. Lloyd, D. L. Robberson, C. W. Haidle

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Non-covalent intermolecular DNA cross-links are created by reaction with the antitumor antibiotic, bleomycin. The cross-links are observed only when the reactant covalently closed circular duplex DNA contains either positive or negative superhelical turns. Multiple sites of cross-linking often extend over 500 base-pairs or more in length.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalChemico-Biological Interactions
Volume34
Issue number1
DOIs
StatePublished - Feb 1981

ASJC Scopus subject areas

  • Toxicology

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