Bleaching toothpaste with two different concentrations of hydrogen peroxide: A randomized double-blinded clinical trial

Hyun Jung Kim, Ji Hyun Jang, Dongseok Choi, Jei Kim, Ji Hee Shim, Duck Su Kim

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objectives: This randomized double-blinded clinical trial evaluated the bleaching efficacy and incidence of contact hypersensitivity of three kinds of bleaching toothpaste. Methods: Forty-nine participants above A2 shade on the maxillary central incisor (#11) and canine (#13) were randomized into three groups: TW group (n = 15), 0.75 % HP-containing toothpaste (Toothwhole white); VL group (n = 15), 0.75 % HP-containing toothpaste (Vussen 7); and VH group (n = 17), 2.8 % of HP-containing toothpaste (Vussen 28). Participants were instructed to manually brush their teeth for 3 min, 3 times per day for 12 weeks. They were followed-up after 4 and 12 weeks. Shade measurements were performed using a spectrophotometer (SP), and data were calculated with CIELab (ΔEab*) and CIEDE2000 (ΔE00) formula. Additionally, visual inspection (VI) using the Vitapan classical shade guide was also performed, and the correlation between the two measurements was analyzed by comparing the CIELab (ΔEab*) values. The incidence of contact hypersensitivity at each follow-up was recorded. A mixed-effect model was performed to assess shade changes and chi-square tests for the incidence of contact hypersensitivity, respectively. Results: At 12 week follow-up, all groups showed ΔEab* above 3.46, and ΔE00 above 2.25 for tooth #11. For tooth #13, the ΔEab* and ΔE00 of VH and TW groups only were above those thresholds. Shade change varied according to toothpaste and follow-up points. SP and VI showed a moderate positive correlation for L*, a*, and b*, respectively (P < 0.05). Contact hypersensitivity was not significantly different among the groups (P > 0.05). Conclusions: Bleaching toothpaste with higher HP yields a better shade change than other toothpaste after 12 weeks. Clinical significance: The use of bleaching toothpaste with a higher HP concentration results in a better shade improvement.

Original languageEnglish (US)
Article number103508
JournalJournal of Dentistry
StatePublished - Dec 2020


  • Bleaching toothpaste
  • Dental bleaching
  • Double-blind clinical study
  • Hydrogen peroxide
  • Hypersensitivity
  • Shade measurement

ASJC Scopus subject areas

  • Dentistry(all)


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