Bladder Volume at Onset of Reflux on Initial Cystogram Predicts Spontaneous Resolution

Zeb M. McMillan, James (Christopher) Austin, Matthew J. Knudson, Charles E. Hawtrey, Christopher S. Cooper

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Purpose: Reflux grade is the factor most commonly used to predict spontaneous reflux resolution. We evaluated other potential predictive factors aside from reflux grade relative to spontaneous resolution. Materials and Methods: We reviewed the records of 20 males and 98 females who were diagnosed with primary vesicoureteral reflux between ages 0 and 7 years between 1990 and 2000. Age, sex, height, weight, reflux grade, bladder volume at onset of reflux and laterality were recorded for the first, second and most recent voiding cystourethrogram or nuclear cystogram before spontaneous resolution or operative intervention. Results: Of 118 patients 75 (64%) had spontaneous resolution, 27 (23%) underwent corrective surgery and 16 (13%) are still being followed. Average age at diagnosis was 2.3 years (range 1 day to 7.7 years) and average followup was 4.3 years (range 0.2 to 14). Average time to spontaneous resolution was 2.2 years (range 0.5 to 10.3) vs a time to operative treatment of 3.6 years (range 0.2 to 11.2). There was a significantly higher spontaneous resolution rate for lower reflux grades (p = 0.0004). Reflux occurring at greater than 75% of predicted bladder capacity had a significantly higher resolution rate (p = 0.0005). The initial height and weight percentile was not significant for predicting spontaneous resolution. Breakthrough urinary tract infections were negative predictors of spontaneous resolution (p

Original languageEnglish (US)
Pages (from-to)1838-1841
Number of pages4
JournalJournal of Urology
Volume176
Issue number4 SUPPL.
DOIs
StatePublished - Oct 2006
Externally publishedYes

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Urinary Bladder
Weights and Measures
Vesico-Ureteral Reflux
Operative Time
Urinary Tract Infections
Cystography
Therapeutics

Keywords

  • bladder
  • prognosis
  • vesico-ureteral reflux

ASJC Scopus subject areas

  • Urology

Cite this

Bladder Volume at Onset of Reflux on Initial Cystogram Predicts Spontaneous Resolution. / McMillan, Zeb M.; Austin, James (Christopher); Knudson, Matthew J.; Hawtrey, Charles E.; Cooper, Christopher S.

In: Journal of Urology, Vol. 176, No. 4 SUPPL., 10.2006, p. 1838-1841.

Research output: Contribution to journalArticle

McMillan, Zeb M. ; Austin, James (Christopher) ; Knudson, Matthew J. ; Hawtrey, Charles E. ; Cooper, Christopher S. / Bladder Volume at Onset of Reflux on Initial Cystogram Predicts Spontaneous Resolution. In: Journal of Urology. 2006 ; Vol. 176, No. 4 SUPPL. pp. 1838-1841.
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