Bivalent biogenic amine reuptake inhibitors

Keith Fandrick, Xianqi Feng, Aaron Janowsky, Robert Johnson, John R. Cashman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A series of aryltropane-based bivalent ligands was prepared and investigated for binding potency and for their ability to inhibit reuptake of human dopamine, serotonin and norepinephrine transporters. The bivalent ligand 4, comprised of linking an aryltropane by an octamethylene spacer showed high efficacy for the human dopamine transporter and had a discrimination ratio of 130.

Original languageEnglish (US)
Pages (from-to)2151-2154
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number13
DOIs
StatePublished - Jul 7 2003
Externally publishedYes

Fingerprint

Dopamine Plasma Membrane Transport Proteins
Biogenic Amines
Norepinephrine Plasma Membrane Transport Proteins
Ligands
Serotonin Plasma Membrane Transport Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Bivalent biogenic amine reuptake inhibitors. / Fandrick, Keith; Feng, Xianqi; Janowsky, Aaron; Johnson, Robert; Cashman, John R.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 13, 07.07.2003, p. 2151-2154.

Research output: Contribution to journalArticle

Fandrick, Keith ; Feng, Xianqi ; Janowsky, Aaron ; Johnson, Robert ; Cashman, John R. / Bivalent biogenic amine reuptake inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 13. pp. 2151-2154.
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