Abstract
The effect of systemic ethanol administration on the extracellular levels of glutamate in the hippocampus and nucleus accumbens of conscious rats was assessed using microdialysis. At 0.5 g/kg, ethanol caused a sustained increase in the levels of glutamate in both regions. Following 1.0 g/kg. response was observed in the nucleus accumbens while a trend towards a decrease in glutamate levels occurred in hippocampus. Injection of 2.0 g/kg ethanol decreased these levels in both regions. These findings suggest a relationship between the previously reported biphasic behavioral consequence of ethanol and its effect on glutamatergic neurotransmission.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 99-102 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 178 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 29 1994 |
| Externally published | Yes |
Keywords
- Ethanol
- Glutamate
- Hippocampus
- Locomotion
- Microdialysis
- Nucleus accumbens
- Reward
ASJC Scopus subject areas
- General Neuroscience