Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens

Bita Moghaddam, Maria L. Bolinao

Research output: Contribution to journalArticle

110 Scopus citations


The effect of systemic ethanol administration on the extracellular levels of glutamate in the hippocampus and nucleus accumbens of conscious rats was assessed using microdialysis. At 0.5 g/kg, ethanol caused a sustained increase in the levels of glutamate in both regions. Following 1.0 g/kg. response was observed in the nucleus accumbens while a trend towards a decrease in glutamate levels occurred in hippocampus. Injection of 2.0 g/kg ethanol decreased these levels in both regions. These findings suggest a relationship between the previously reported biphasic behavioral consequence of ethanol and its effect on glutamatergic neurotransmission.

Original languageEnglish (US)
Pages (from-to)99-102
Number of pages4
JournalNeuroscience Letters
Issue number1
StatePublished - Aug 29 1994



  • Ethanol
  • Glutamate
  • Hippocampus
  • Locomotion
  • Microdialysis
  • Nucleus accumbens
  • Reward

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this