Biomechanics of early cardiac development

Sevan Goenezen, Monique Y. Rennie, Sandra Rugonyi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Biomechanics affect early cardiac development, from looping to the development of chambers and valves. Hemodynamic forces are essential for proper cardiac development, and their disruption leads to congenital heart defects. A wealth of information already exists on early cardiac adaptations to hemodynamic loading, and new technologies, including high-resolution imaging modalities and computational modeling, are enabling amore thorough understanding of relationships between hemodynamics and cardiac development. Imaging and modeling approaches, used in combination with biological data on cell behavior and adaptation, are paving the road for new discoveries on links between biomechanics and biology and their effect on cardiac development and fetal programming.

Original languageEnglish (US)
Pages (from-to)1187-1204
Number of pages18
JournalBiomechanics and Modeling in Mechanobiology
Volume11
Issue number8
DOIs
StatePublished - Nov 2012

Fingerprint

Biomechanics
Hemodynamics
Biomechanical Phenomena
Cardiac
Imaging techniques
Congenital Heart Defects
Fetal Development
High Resolution Imaging
Computational Modeling
Technology
Defects
Modality
Biology
Programming
Imaging
Cell
Modeling

Keywords

  • Blood flow modeling
  • Cardiogenesis
  • Computational biomechanics
  • Computational modeling
  • Early cardiac development
  • Valveless pumping

ASJC Scopus subject areas

  • Biotechnology
  • Mechanical Engineering
  • Modeling and Simulation

Cite this

Biomechanics of early cardiac development. / Goenezen, Sevan; Rennie, Monique Y.; Rugonyi, Sandra.

In: Biomechanics and Modeling in Mechanobiology, Vol. 11, No. 8, 11.2012, p. 1187-1204.

Research output: Contribution to journalArticle

Goenezen, Sevan ; Rennie, Monique Y. ; Rugonyi, Sandra. / Biomechanics of early cardiac development. In: Biomechanics and Modeling in Mechanobiology. 2012 ; Vol. 11, No. 8. pp. 1187-1204.
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