Biomechanics of early cardiac development

Sevan Goenezen, Monique Y. Rennie, Sandra Rugonyi

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Biomechanics affect early cardiac development, from looping to the development of chambers and valves. Hemodynamic forces are essential for proper cardiac development, and their disruption leads to congenital heart defects. A wealth of information already exists on early cardiac adaptations to hemodynamic loading, and new technologies, including high-resolution imaging modalities and computational modeling, are enabling amore thorough understanding of relationships between hemodynamics and cardiac development. Imaging and modeling approaches, used in combination with biological data on cell behavior and adaptation, are paving the road for new discoveries on links between biomechanics and biology and their effect on cardiac development and fetal programming.

Original languageEnglish (US)
Pages (from-to)1187-1204
Number of pages18
JournalBiomechanics and Modeling in Mechanobiology
Volume11
Issue number8
DOIs
StatePublished - Nov 2012

Keywords

  • Blood flow modeling
  • Cardiogenesis
  • Computational biomechanics
  • Computational modeling
  • Early cardiac development
  • Valveless pumping

ASJC Scopus subject areas

  • Biotechnology
  • Modeling and Simulation
  • Mechanical Engineering

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