Biologie de l'axe somatotrope (après l'hypophyse)

Translated title of the contribution: Biology of the somatotroph axis (after the pituitary)

Ron G. Rosenfeld, Vivian Hwa

Research output: Contribution to journalArticle

Abstract

Normal growth requires that pituitary-secreted growth hormone (GH) bind to its specific receptor and activate a complex signaling cascade, leaving to production of insulin-like growth factor-I (IGF-I), which, in turn, activates its own receptor (IGF1R). The GH receptor (GHR) is preformed as a dimer and is transported in a nonligand bound state to the cell surface. Binding of GH to the GHR dimer, results in a conformational change of the dimer, activation of the intracellular Janus Kinase 2 (JAK2) and phosphorylation of signal transducer and activator of transcription (STAT) 5B. Phosphorylated STAT5B dimers are then translocated to the nucleus, where they transcriptionally activate multiple genes, including those for IGF-I, IGF binding protein-3 and the acid-labile subunit (ALS).

Translated title of the contributionBiology of the somatotroph axis (after the pituitary)
Original languageFrench
Pages (from-to)80-82
Number of pages3
JournalAnnales d'Endocrinologie
Volume78
Issue number2
DOIs
StatePublished - Jun 2017

Keywords

  • GH
  • GHR function
  • Somatotroph axis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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