Biologie de l'axe somatotrope (après l'hypophyse)

Translated title of the contribution: Biology of the somatotroph axis (after the pituitary)

Ronald (Ron) Rosenfeld, Vivian Hwa

Research output: Contribution to journalArticle

Abstract

Normal growth requires that pituitary-secreted growth hormone (GH) bind to its specific receptor and activate a complex signaling cascade, leaving to production of insulin-like growth factor-I (IGF-I), which, in turn, activates its own receptor (IGF1R). The GH receptor (GHR) is preformed as a dimer and is transported in a nonligand bound state to the cell surface. Binding of GH to the GHR dimer, results in a conformational change of the dimer, activation of the intracellular Janus Kinase 2 (JAK2) and phosphorylation of signal transducer and activator of transcription (STAT) 5B. Phosphorylated STAT5B dimers are then translocated to the nucleus, where they transcriptionally activate multiple genes, including those for IGF-I, IGF binding protein-3 and the acid-labile subunit (ALS).

Original languageFrench
Pages (from-to)80-82
Number of pages3
JournalAnnales d'Endocrinologie
Volume78
Issue number2
DOIs
StatePublished - Jun 1 2017

Fingerprint

Somatotrophs
Insulin-Like Growth Factor I
Growth Hormone
STAT5 Transcription Factor
Janus Kinase 2
Somatotropin Receptors
Insulin-Like Growth Factor Binding Protein 3
Phosphorylation
Acids
Growth
Genes

Keywords

  • GH
  • GHR function
  • Somatotroph axis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Biologie de l'axe somatotrope (après l'hypophyse). / Rosenfeld, Ronald (Ron); Hwa, Vivian.

In: Annales d'Endocrinologie, Vol. 78, No. 2, 01.06.2017, p. 80-82.

Research output: Contribution to journalArticle

Rosenfeld, Ronald (Ron) ; Hwa, Vivian. / Biologie de l'axe somatotrope (après l'hypophyse). In: Annales d'Endocrinologie. 2017 ; Vol. 78, No. 2. pp. 80-82.
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