Biological variability of blood omega-3 biomarkers

William Harris, Rachael M. Thomas

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Objectives: We conducted a pilot study to estimate the biological variability and effects of a prior meal on the omega-3 fatty acid (FA) content of 3 blood FA pools. Design and methods: We measured FA levels in red blood cells (RBCs), plasma and plasma phospholipids (PL) obtained from 20 healthy volunteers tested weekly over 6 weeks. Results: The within-subject coefficients of variation were 4.1% ± 1.9%, 15.9% ± 6.4%, and 14.5% ± 8.4%, respectively (RBC vs. others, p <0.001). RBC omega-3 FA content had the lowest biological variability and was not altered in the fed state. Conclusions: From the perspective of variability and of the sample types tested, RBCs may be the preferred sample type for assessing omega-3 FA status.

Original languageEnglish (US)
Pages (from-to)338-340
Number of pages3
JournalClinical Biochemistry
Volume43
Issue number3
DOIs
StatePublished - Feb 2010
Externally publishedYes

Fingerprint

Biomarkers
Omega-3 Fatty Acids
Blood
Erythrocytes
Fatty Acids
Plasmas
Meals
Phospholipids
Healthy Volunteers
Cells

Keywords

  • Biomarker
  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Erythrocytes
  • Plasma
  • Plasma phospholipids

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Biological variability of blood omega-3 biomarkers. / Harris, William; Thomas, Rachael M.

In: Clinical Biochemistry, Vol. 43, No. 3, 02.2010, p. 338-340.

Research output: Contribution to journalArticle

Harris, William ; Thomas, Rachael M. / Biological variability of blood omega-3 biomarkers. In: Clinical Biochemistry. 2010 ; Vol. 43, No. 3. pp. 338-340.
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