Biological markers in head and neck cancer

Myriam Loyo, M. L. Poeta, J. A. Califano

Research output: Contribution to journalArticle

Abstract

As our understanding of the molecular biology of cancer continues to grow, tumor biomarkers have began to emerge as potential clinical tools. In the present review we will discuss prominent biomarkers in head and neck squamous cell carcinomas (HNSCC). Human papillomavirus (HPV) is the etiology agent in a subgroup of non-smoker, young patients carrying a favorable prognosis. Epidermal growth factor receptor (EGFR) overexpression is commonly present in HNSCC that can be now be targeted by new drugs. The well-known tumor suppressor gene p53 is known to be altered in a vast majority of human cancers. In HNSCC, prognosis is adversely affected by loss of p53. Other markers such as epigenetic alterations, mitochondrial dysfunction, and loss of heterozygosity are addressed in the text. This review emphasizes evidence based diagnostic, staging, monitoring, prognostic, and treatment implications of these biomarkers.

Original languageEnglish (US)
Pages (from-to)119-131
Number of pages13
JournalOtorinolaringologia
Volume59
Issue number3
StatePublished - Sep 2009
Externally publishedYes

Fingerprint

Head and Neck Neoplasms
Biomarkers
Loss of Heterozygosity
Tumor Biomarkers
Tumor Suppressor Genes
Epidermal Growth Factor Receptor
Epigenomics
Molecular Biology
Neoplasms
Pharmaceutical Preparations
Carcinoma, squamous cell of head and neck
Therapeutics

Keywords

  • Biological markers
  • DNA
  • Epidermal growth factor
  • Epigenesis
  • Genetic
  • Head and neck neoplasms
  • Loss of heterozygosity
  • Mitochondrial
  • Molecular biology
  • Receptor

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Loyo, M., Poeta, M. L., & Califano, J. A. (2009). Biological markers in head and neck cancer. Otorinolaringologia, 59(3), 119-131.

Biological markers in head and neck cancer. / Loyo, Myriam; Poeta, M. L.; Califano, J. A.

In: Otorinolaringologia, Vol. 59, No. 3, 09.2009, p. 119-131.

Research output: Contribution to journalArticle

Loyo, M, Poeta, ML & Califano, JA 2009, 'Biological markers in head and neck cancer', Otorinolaringologia, vol. 59, no. 3, pp. 119-131.
Loyo M, Poeta ML, Califano JA. Biological markers in head and neck cancer. Otorinolaringologia. 2009 Sep;59(3):119-131.
Loyo, Myriam ; Poeta, M. L. ; Califano, J. A. / Biological markers in head and neck cancer. In: Otorinolaringologia. 2009 ; Vol. 59, No. 3. pp. 119-131.
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