Abstract
Ammonium- and imidazolium-based ionic salts were studied for their application as inhibitors of HIV-1 integrase (IN). These compounds were active in the inhibition of both the 3′-processing (3′-P) and strand transfer (ST) steps of the integration reaction. A correlation of activity with chain length of the alkyl substituent in both classes of ionic salts was observed.
Original language | English (US) |
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Pages (from-to) | 143-150 |
Number of pages | 8 |
Journal | MedChemComm |
Volume | 2 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2011 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry