Biological evaluation of imidazolium- and ammonium-based salts as HIV-1 integrase inhibitors

Kasthuraiah Maddali; Vineet Kumar; Christophe Marchand; Yves Pommier; Sanjay V. Malhotra

doi:10.1039/c0md00201a

Biological evaluation of imidazolium- and ammonium-based salts as HIV-1 integrase inhibitors

Kasthuraiah Maddali, Vineet Kumar, Christophe Marchand, Yves Pommier, Sanjay V. Malhotra

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Ammonium- and imidazolium-based ionic salts were studied for their application as inhibitors of HIV-1 integrase (IN). These compounds were active in the inhibition of both the 3′-processing (3′-P) and strand transfer (ST) steps of the integration reaction. A correlation of activity with chain length of the alkyl substituent in both classes of ionic salts was observed.

Original language	English (US)
Pages (from-to)	143-150
Number of pages	8
Journal	MedChemComm
Volume	2
Issue number	2
DOIs	https://doi.org/10.1039/c0md00201a
State	Published - Feb 2011
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

Access to Document

10.1039/c0md00201a

Cite this

@article{7d1f598a5ec7439e99f87edc7d9b5ab3,

title = "Biological evaluation of imidazolium- and ammonium-based salts as HIV-1 integrase inhibitors",

abstract = "Ammonium- and imidazolium-based ionic salts were studied for their application as inhibitors of HIV-1 integrase (IN). These compounds were active in the inhibition of both the 3′-processing (3′-P) and strand transfer (ST) steps of the integration reaction. A correlation of activity with chain length of the alkyl substituent in both classes of ionic salts was observed.",

author = "Kasthuraiah Maddali and Vineet Kumar and Christophe Marchand and Yves Pommier and Malhotra, {Sanjay V.}",

year = "2011",

month = feb,

doi = "10.1039/c0md00201a",

language = "English (US)",

volume = "2",

pages = "143--150",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "2",

}

TY - JOUR

T1 - Biological evaluation of imidazolium- and ammonium-based salts as HIV-1 integrase inhibitors

AU - Maddali, Kasthuraiah

AU - Kumar, Vineet

AU - Marchand, Christophe

AU - Pommier, Yves

AU - Malhotra, Sanjay V.

PY - 2011/2

Y1 - 2011/2

N2 - Ammonium- and imidazolium-based ionic salts were studied for their application as inhibitors of HIV-1 integrase (IN). These compounds were active in the inhibition of both the 3′-processing (3′-P) and strand transfer (ST) steps of the integration reaction. A correlation of activity with chain length of the alkyl substituent in both classes of ionic salts was observed.

AB - Ammonium- and imidazolium-based ionic salts were studied for their application as inhibitors of HIV-1 integrase (IN). These compounds were active in the inhibition of both the 3′-processing (3′-P) and strand transfer (ST) steps of the integration reaction. A correlation of activity with chain length of the alkyl substituent in both classes of ionic salts was observed.

UR - http://www.scopus.com/inward/record.url?scp=79952513453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952513453&partnerID=8YFLogxK

U2 - 10.1039/c0md00201a

DO - 10.1039/c0md00201a

M3 - Article

AN - SCOPUS:79952513453

SN - 2040-2503

VL - 2

SP - 143

EP - 150

JO - MedChemComm

JF - MedChemComm

IS - 2

ER -

Biological evaluation of imidazolium- and ammonium-based salts as HIV-1 integrase inhibitors

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this