Biological activity of canine intestinal cholecystokinin-58

V. E. Eysselein, C. W. Deveney, H. Sankaran

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The biological activity of a recently characterized cholecystokinin molecule, canine CCK-58, has been tested using perifused canine gallbladder strips and isolated mouse pancreatic acini. It has been shown that canine CCK-58, purified by affinity chromatography and molecular sieve chromatography, is biologically as potent as canine CCK-39,33 (Component II) and synthetic CCK-8. The biological responses were inhibited by dibutyryl cGMP, a known CCK antagonist. CCK-58 is one of the main large molecular forms of CCK in the intestine mucosa. Whether CCK-58 is only an intracellular precursor of other CCK molecules or an important circulating hormone cannot be determined from the data currently available.

Original languageEnglish (US)
Pages (from-to)G313-G320
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number2
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)


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