Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma

James V. Tricoli, Donald G. Blair, Carey K. Anders, W. Archie Bleyer, Lisa A. Boardman, Javed Khan, Shivaani Kummar, Brandon Hayes-Lattin, Stephen P. Hunger, Melinda Merchant, Nita L. Seibel, Magdalena Thurin, Cheryl L. Willman

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Adolescent and young adult (AYA) patients with cancer have not attained the same improvements in overall survival as either younger children or older adults. One possible reason for this disparity may be that the AYA cancers exhibit unique biologic characteristics, resulting in differences in clinical and treatment resistance behaviors. This report from the biologic component of the jointly sponsored National Cancer Institute and LiveStrong Foundation workshop entitled "Next Steps in Adolescent and Young Adult Oncology" summarizes the current status of biologic and translational research progress for 5 AYA cancers; colorectal cancer breast cancer, acute lymphoblastic leukemia, melanoma, and sarcoma. Conclusions from this meeting included the need for basic biologic, genomic, and model development for AYA cancers as well as translational research studies to elucidate any fundamental differences between pediatric, AYA, and adult cancers. The biologic questions for future research are whether there are mutational or signaling pathway differences (for example, between adult and AYA colorectal cancer) that can be clinically exploited to develop novel therapies for treating AYA cancers and to develop companion diagnostics.

Original languageEnglish (US)
Pages (from-to)1017-1028
Number of pages12
JournalCancer
Volume122
Issue number7
DOIs
StatePublished - Apr 1 2016

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sarcoma
Young Adult
Colorectal Neoplasms
Melanoma
Breast Neoplasms
Neoplasms
Translational Medical Research
Adolescent Development
Biological Models
National Cancer Institute (U.S.)
Pediatrics
Education
Survival
Therapeutics

Keywords

  • acute lymphoblastic leukemia (ALL)
  • breast
  • colorectal
  • melanoma
  • sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Tricoli, J. V., Blair, D. G., Anders, C. K., Bleyer, W. A., Boardman, L. A., Khan, J., ... Willman, C. L. (2016). Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma. Cancer, 122(7), 1017-1028. https://doi.org/10.1002/cncr.29871

Biologic and clinical characteristics of adolescent and young adult cancers : Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma. / Tricoli, James V.; Blair, Donald G.; Anders, Carey K.; Bleyer, W. Archie; Boardman, Lisa A.; Khan, Javed; Kummar, Shivaani; Hayes-Lattin, Brandon; Hunger, Stephen P.; Merchant, Melinda; Seibel, Nita L.; Thurin, Magdalena; Willman, Cheryl L.

In: Cancer, Vol. 122, No. 7, 01.04.2016, p. 1017-1028.

Research output: Contribution to journalArticle

Tricoli, JV, Blair, DG, Anders, CK, Bleyer, WA, Boardman, LA, Khan, J, Kummar, S, Hayes-Lattin, B, Hunger, SP, Merchant, M, Seibel, NL, Thurin, M & Willman, CL 2016, 'Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma', Cancer, vol. 122, no. 7, pp. 1017-1028. https://doi.org/10.1002/cncr.29871
Tricoli, James V. ; Blair, Donald G. ; Anders, Carey K. ; Bleyer, W. Archie ; Boardman, Lisa A. ; Khan, Javed ; Kummar, Shivaani ; Hayes-Lattin, Brandon ; Hunger, Stephen P. ; Merchant, Melinda ; Seibel, Nita L. ; Thurin, Magdalena ; Willman, Cheryl L. / Biologic and clinical characteristics of adolescent and young adult cancers : Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma. In: Cancer. 2016 ; Vol. 122, No. 7. pp. 1017-1028.
@article{8f6249ea7b134aea8333fdbf6988f85c,
title = "Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma",
abstract = "Adolescent and young adult (AYA) patients with cancer have not attained the same improvements in overall survival as either younger children or older adults. One possible reason for this disparity may be that the AYA cancers exhibit unique biologic characteristics, resulting in differences in clinical and treatment resistance behaviors. This report from the biologic component of the jointly sponsored National Cancer Institute and LiveStrong Foundation workshop entitled {"}Next Steps in Adolescent and Young Adult Oncology{"} summarizes the current status of biologic and translational research progress for 5 AYA cancers; colorectal cancer breast cancer, acute lymphoblastic leukemia, melanoma, and sarcoma. Conclusions from this meeting included the need for basic biologic, genomic, and model development for AYA cancers as well as translational research studies to elucidate any fundamental differences between pediatric, AYA, and adult cancers. The biologic questions for future research are whether there are mutational or signaling pathway differences (for example, between adult and AYA colorectal cancer) that can be clinically exploited to develop novel therapies for treating AYA cancers and to develop companion diagnostics.",
keywords = "acute lymphoblastic leukemia (ALL), breast, colorectal, melanoma, sarcoma",
author = "Tricoli, {James V.} and Blair, {Donald G.} and Anders, {Carey K.} and Bleyer, {W. Archie} and Boardman, {Lisa A.} and Javed Khan and Shivaani Kummar and Brandon Hayes-Lattin and Hunger, {Stephen P.} and Melinda Merchant and Seibel, {Nita L.} and Magdalena Thurin and Willman, {Cheryl L.}",
year = "2016",
month = "4",
day = "1",
doi = "10.1002/cncr.29871",
language = "English (US)",
volume = "122",
pages = "1017--1028",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "7",

}

TY - JOUR

T1 - Biologic and clinical characteristics of adolescent and young adult cancers

T2 - Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma

AU - Tricoli, James V.

AU - Blair, Donald G.

AU - Anders, Carey K.

AU - Bleyer, W. Archie

AU - Boardman, Lisa A.

AU - Khan, Javed

AU - Kummar, Shivaani

AU - Hayes-Lattin, Brandon

AU - Hunger, Stephen P.

AU - Merchant, Melinda

AU - Seibel, Nita L.

AU - Thurin, Magdalena

AU - Willman, Cheryl L.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Adolescent and young adult (AYA) patients with cancer have not attained the same improvements in overall survival as either younger children or older adults. One possible reason for this disparity may be that the AYA cancers exhibit unique biologic characteristics, resulting in differences in clinical and treatment resistance behaviors. This report from the biologic component of the jointly sponsored National Cancer Institute and LiveStrong Foundation workshop entitled "Next Steps in Adolescent and Young Adult Oncology" summarizes the current status of biologic and translational research progress for 5 AYA cancers; colorectal cancer breast cancer, acute lymphoblastic leukemia, melanoma, and sarcoma. Conclusions from this meeting included the need for basic biologic, genomic, and model development for AYA cancers as well as translational research studies to elucidate any fundamental differences between pediatric, AYA, and adult cancers. The biologic questions for future research are whether there are mutational or signaling pathway differences (for example, between adult and AYA colorectal cancer) that can be clinically exploited to develop novel therapies for treating AYA cancers and to develop companion diagnostics.

AB - Adolescent and young adult (AYA) patients with cancer have not attained the same improvements in overall survival as either younger children or older adults. One possible reason for this disparity may be that the AYA cancers exhibit unique biologic characteristics, resulting in differences in clinical and treatment resistance behaviors. This report from the biologic component of the jointly sponsored National Cancer Institute and LiveStrong Foundation workshop entitled "Next Steps in Adolescent and Young Adult Oncology" summarizes the current status of biologic and translational research progress for 5 AYA cancers; colorectal cancer breast cancer, acute lymphoblastic leukemia, melanoma, and sarcoma. Conclusions from this meeting included the need for basic biologic, genomic, and model development for AYA cancers as well as translational research studies to elucidate any fundamental differences between pediatric, AYA, and adult cancers. The biologic questions for future research are whether there are mutational or signaling pathway differences (for example, between adult and AYA colorectal cancer) that can be clinically exploited to develop novel therapies for treating AYA cancers and to develop companion diagnostics.

KW - acute lymphoblastic leukemia (ALL)

KW - breast

KW - colorectal

KW - melanoma

KW - sarcoma

UR - http://www.scopus.com/inward/record.url?scp=84961793715&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961793715&partnerID=8YFLogxK

U2 - 10.1002/cncr.29871

DO - 10.1002/cncr.29871

M3 - Article

C2 - 26849082

AN - SCOPUS:84961793715

VL - 122

SP - 1017

EP - 1028

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 7

ER -