Bioinformatics and systems biology

Prahlad T. Ram, John Mendelsohn, Gordon B. Mills

    Research output: Contribution to journalReview article

    11 Scopus citations

    Abstract

    Delivering personalized therapeutic options to cancer patients based on the genetic and molecular aberrations of the tumor offers great promise to improve the outcomes of cancer therapy. Significant progress in biotechnology has allowed the measurement of tens of thousands of "omic" data points across multiple levels (DNA, RNA protein, metabolomics) from a single tumor biopsy sample in a reasonable time frame for making clinical decisions. With this data in hand, the challenge from the bioinformatics and systems biology point of view is how does one convert data into information and knowledge that can improve the delivery of personalized therapy to the patient.

    Original languageEnglish (US)
    Pages (from-to)147-154
    Number of pages8
    JournalMolecular Oncology
    Volume6
    Issue number2
    DOIs
    StatePublished - Apr 2012

    Keywords

    • Personalized cancer therapy
    • Predictive model systems
    • Systens biology

    ASJC Scopus subject areas

    • Molecular Medicine
    • Genetics
    • Oncology
    • Cancer Research

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