Bioinformatics and systems biology

Prahlad T. Ram; John Mendelsohn; Gordon B. Mills

doi:10.1016/j.molonc.2012.01.008

Bioinformatics and systems biology

Prahlad T. Ram, John Mendelsohn, Gordon B. Mills

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Delivering personalized therapeutic options to cancer patients based on the genetic and molecular aberrations of the tumor offers great promise to improve the outcomes of cancer therapy. Significant progress in biotechnology has allowed the measurement of tens of thousands of "omic" data points across multiple levels (DNA, RNA protein, metabolomics) from a single tumor biopsy sample in a reasonable time frame for making clinical decisions. With this data in hand, the challenge from the bioinformatics and systems biology point of view is how does one convert data into information and knowledge that can improve the delivery of personalized therapy to the patient.

Original language	English (US)
Pages (from-to)	147-154
Number of pages	8
Journal	Molecular Oncology
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/j.molonc.2012.01.008
State	Published - Apr 2012
Externally published	Yes

Keywords

Personalized cancer therapy
Predictive model systems
Systens biology

ASJC Scopus subject areas

Molecular Medicine
Genetics
Oncology
Cancer Research

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10.1016/j.molonc.2012.01.008

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AU - Mendelsohn, John

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AB - Delivering personalized therapeutic options to cancer patients based on the genetic and molecular aberrations of the tumor offers great promise to improve the outcomes of cancer therapy. Significant progress in biotechnology has allowed the measurement of tens of thousands of "omic" data points across multiple levels (DNA, RNA protein, metabolomics) from a single tumor biopsy sample in a reasonable time frame for making clinical decisions. With this data in hand, the challenge from the bioinformatics and systems biology point of view is how does one convert data into information and knowledge that can improve the delivery of personalized therapy to the patient.

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KW - Predictive model systems

KW - Systens biology

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Bioinformatics and systems biology

Abstract

Keywords

ASJC Scopus subject areas

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