Biofilms in Root Canal Infections

Christine Sedgley, Rogério de Castilho Jacinto

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter describes the general characteristics of biofilms and analyzes biofilms associated with root canal (RC) infections. Microbial cells occupy only a small portion of the biofilm. The majority of the biofilm structure is a highly heterogeneous matrix composed of extracellular polymeric substances (EPS) produced by cells within the biofilm. The distance between microorganisms and their spatial distribution within biofilms are critical factors for intermicrobial communication processes in biofilms. In the ever-changing biofilm environment, microbial cells encounter a multitude of stresses and challenges. These include exposure to nutrient limitation, reactive oxygen and nitrogen species, membrane damage, and elevated temperature. Infected RCs harbor a multispecies population of facultative and strict anaerobic gram-positive and gram-negative bacteria, spirochetes, yeasts, archaea, and other unidentified species. Several in-vitro models have been used to study biofilms of relevance to RC treatment. These studies typically focus on the efficacy of antimicrobial agents against single- or multispecies biofilms.

Original languageEnglish (US)
Title of host publicationDisinfection of Root Canal Systems: The Treatment of Apical Periodontitis
PublisherWiley Blackwell
Pages29-56
Number of pages28
ISBN (Print)9781118914014, 9781118367681
DOIs
StatePublished - Sep 15 2014

Fingerprint

Dental Pulp Cavity
Biofilms
Infection
Reactive Nitrogen Species
Spirochaetales
Archaea
Anti-Infective Agents
Gram-Negative Bacteria
Extracellular Matrix
Reactive Oxygen Species
Yeasts
Food
Temperature
Membranes

Keywords

  • Biofilms
  • Extracellular polymeric substances (EPS)
  • Root canal (RC) infections

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Sedgley, C., & Jacinto, R. D. C. (2014). Biofilms in Root Canal Infections. In Disinfection of Root Canal Systems: The Treatment of Apical Periodontitis (pp. 29-56). Wiley Blackwell. https://doi.org/10.1002/9781118914014.ch3

Biofilms in Root Canal Infections. / Sedgley, Christine; Jacinto, Rogério de Castilho.

Disinfection of Root Canal Systems: The Treatment of Apical Periodontitis. Wiley Blackwell, 2014. p. 29-56.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sedgley, C & Jacinto, RDC 2014, Biofilms in Root Canal Infections. in Disinfection of Root Canal Systems: The Treatment of Apical Periodontitis. Wiley Blackwell, pp. 29-56. https://doi.org/10.1002/9781118914014.ch3
Sedgley C, Jacinto RDC. Biofilms in Root Canal Infections. In Disinfection of Root Canal Systems: The Treatment of Apical Periodontitis. Wiley Blackwell. 2014. p. 29-56 https://doi.org/10.1002/9781118914014.ch3
Sedgley, Christine ; Jacinto, Rogério de Castilho. / Biofilms in Root Canal Infections. Disinfection of Root Canal Systems: The Treatment of Apical Periodontitis. Wiley Blackwell, 2014. pp. 29-56
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