Biocompatible core-shell magnetic nanoparticles for cancer treatment

Amit Sharma, You Qiang, Daniel Meyer, Ryan Souza, Alan McConnaughoy, Leslie Muldoon, Donald Baer

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Nontoxic magnetic nanoparticles (MNPs) have expanded treatment delivery options in the medical world. With a size range from 2 to 200 nm, MNPs can be compiled with most of the small cells and tissues in the living body. Monodispersive iron-iron oxide core-shell nanoparticles were prepared by our novel cluster deposition system. This unique method of preparing core-shell MNPs gives the nanoparticles a very high magnetic moment. We tested the nontoxicity and uptake of MNPs coated with/without dextrin by incubating them with rat LX-1 small cell lung cancer cells. Since core iron enhances the heating effect [L. Baker, Q. Zeing, W. Li, and S. Sullivan, J. Appl. Phys. 99, 08H106 (2006)], the rate of oxidation of iron nanoparticles was also tested in de-ionized water at a certain time interval. Both coated and noncoated MNPs were successfully uptaken by the cells, indicating that the nanoparticles were not toxic. The stability of MNPs was verified by x-ray diffraction scan after 0, 24, 48, 96, and 204 h. Due to the high magnetic moment offered by MNPs produced in our laboratory, we predict that even at low applied external alternating field, the desired temperature could be reached in cancer cells in comparison to the commercially available nanoparticles. Moreover our MNPs do not require additional transfection agent, providing a cost effective means of treatment with significantly lower dosage in the body in comparison to commercially available nanoparticles.

Original languageEnglish (US)
Article number07A308
JournalJournal of Applied Physics
Volume103
Issue number7
DOIs
StatePublished - 2008

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cancer
nanoparticles
iron
magnetic moments
cells
iron oxides
lungs
rats
delivery
x ray diffraction
costs
intervals
dosage
oxidation
heating

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)
  • Physics and Astronomy(all)

Cite this

Sharma, A., Qiang, Y., Meyer, D., Souza, R., McConnaughoy, A., Muldoon, L., & Baer, D. (2008). Biocompatible core-shell magnetic nanoparticles for cancer treatment. Journal of Applied Physics, 103(7), [07A308]. https://doi.org/10.1063/1.2831791

Biocompatible core-shell magnetic nanoparticles for cancer treatment. / Sharma, Amit; Qiang, You; Meyer, Daniel; Souza, Ryan; McConnaughoy, Alan; Muldoon, Leslie; Baer, Donald.

In: Journal of Applied Physics, Vol. 103, No. 7, 07A308, 2008.

Research output: Contribution to journalArticle

Sharma, A, Qiang, Y, Meyer, D, Souza, R, McConnaughoy, A, Muldoon, L & Baer, D 2008, 'Biocompatible core-shell magnetic nanoparticles for cancer treatment', Journal of Applied Physics, vol. 103, no. 7, 07A308. https://doi.org/10.1063/1.2831791
Sharma, Amit ; Qiang, You ; Meyer, Daniel ; Souza, Ryan ; McConnaughoy, Alan ; Muldoon, Leslie ; Baer, Donald. / Biocompatible core-shell magnetic nanoparticles for cancer treatment. In: Journal of Applied Physics. 2008 ; Vol. 103, No. 7.
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