Biochemical diagnostic strategies in the evaluation of short stature: The diagnosis of insulin-like growth factor deficiency

Ron G. Rosenfeld

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The cornerstones in the evaluation of short stature are auxology and biochemical testing. Traditionally, the diagnosis of growth hormone (GH) deficiency has been based upon measurement of serum concentrations of GH following either physiological or pharmacological stimulation, or determination of spontaneous GH secretory patterns. Assessment of pituitary GH secretion is, however, fraught with problems, including the nonphysiological nature of provocative testing, the reliance on arbitrary definitions of subnormal responses, the inadequate attention paid to age- and puberty-related variability, and the dependence upon assays with marginal concordancy. It is proposed that the evaluation of short stature is best pursued by careful auxology plus assessment of the insulin-like growth factor (IGF) axis, with particular attention to measurements of serum concentrations of IGF-I and IGF-binding protein-3. The diagnosis of IGF deficiency can then be readily established, and its etiology pursued logically.

Original languageEnglish (US)
Pages (from-to)170-173
Number of pages4
JournalHormone Research in Paediatrics
Volume46
Issue number4-5
DOIs
StatePublished - Jan 1996

Keywords

  • Growth
  • Growth hormone
  • Growth hormone deficiency
  • Insulin-like growth factor
  • Insulin-like growth factor deficiency
  • Insulin-like growth factor-binding protein

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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