Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma

Jennifer L. Bayer, Douglas R. Spitz, Desire Christensen, Michael L. McCormick, Donna Farley, Koenraad De Geest, Laila Damoush, Samantha Aust, Anil K. Sood, Susan K. Lutgendorf

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Increased levels of reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide have been reported in many cancer cells and they have been implicated in carcinogenesis and tumor progression. Antioxidant enzymes, such as Manganese Superoxide Dismutase (MnSOD or SOD2) and Glutathione Peroxidase-1 (GPx1), act coordinately to neutralize ROS. These enzymes are also thought to contribute to cancer cell resistance to conventional radio-chemo-therapies. Although some relationships have been reported between psychosocial factors and the regulation of antioxidant enzymes, little is known about these relationships in the context of cancer progression.The current study investigated the levels of MnSOD and GPx1in confirmed serous, high-grade tumor tissue from 60 ovarian cancer patients, and explored the relationship between the activity of these enzymes, the levels of tumor norepinephrine (NE), and patient mood as determined via pre-operative questionnaires. MnSOD activity was positively related to depressed mood (p = 0.025) and tumor NE (p = 0.023). In contrast, GPx1 activity was inversely related to fatigue (p = 0.015) and tumor NE (p = 0.009), and was positively associated with vigor (p = 0.024). These findings suggest that psychological state and adrenergic signaling are linked with antioxidant enzyme activity in ovarian cancer and may have implications for patient treatments and outcomes.

Original languageEnglish (US)
JournalBrain, Behavior, and Immunity
DOIs
StateAccepted/In press - Jan 11 2015

Fingerprint

Antioxidants
Carcinoma
Enzymes
Neoplasms
Norepinephrine
Ovarian Neoplasms
Reactive Oxygen Species
Psychology
Radio
Superoxides
Adrenergic Agents
Hydrogen Peroxide
Superoxide Dismutase
Fatigue
Carcinogenesis

Keywords

  • Antioxidant enzymes
  • Biobehavioral
  • Neuroendocrine
  • Ovarian cancer
  • Stress

ASJC Scopus subject areas

  • Immunology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Bayer, J. L., Spitz, D. R., Christensen, D., McCormick, M. L., Farley, D., De Geest, K., ... Lutgendorf, S. K. (Accepted/In press). Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma. Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2015.04.019

Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma. / Bayer, Jennifer L.; Spitz, Douglas R.; Christensen, Desire; McCormick, Michael L.; Farley, Donna; De Geest, Koenraad; Damoush, Laila; Aust, Samantha; Sood, Anil K.; Lutgendorf, Susan K.

In: Brain, Behavior, and Immunity, 11.01.2015.

Research output: Contribution to journalArticle

Bayer, JL, Spitz, DR, Christensen, D, McCormick, ML, Farley, D, De Geest, K, Damoush, L, Aust, S, Sood, AK & Lutgendorf, SK 2015, 'Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma', Brain, Behavior, and Immunity. https://doi.org/10.1016/j.bbi.2015.04.019
Bayer, Jennifer L. ; Spitz, Douglas R. ; Christensen, Desire ; McCormick, Michael L. ; Farley, Donna ; De Geest, Koenraad ; Damoush, Laila ; Aust, Samantha ; Sood, Anil K. ; Lutgendorf, Susan K. / Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma. In: Brain, Behavior, and Immunity. 2015.
@article{295d6f7de7d941da98ef857da1cab844,
title = "Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma",
abstract = "Increased levels of reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide have been reported in many cancer cells and they have been implicated in carcinogenesis and tumor progression. Antioxidant enzymes, such as Manganese Superoxide Dismutase (MnSOD or SOD2) and Glutathione Peroxidase-1 (GPx1), act coordinately to neutralize ROS. These enzymes are also thought to contribute to cancer cell resistance to conventional radio-chemo-therapies. Although some relationships have been reported between psychosocial factors and the regulation of antioxidant enzymes, little is known about these relationships in the context of cancer progression.The current study investigated the levels of MnSOD and GPx1in confirmed serous, high-grade tumor tissue from 60 ovarian cancer patients, and explored the relationship between the activity of these enzymes, the levels of tumor norepinephrine (NE), and patient mood as determined via pre-operative questionnaires. MnSOD activity was positively related to depressed mood (p = 0.025) and tumor NE (p = 0.023). In contrast, GPx1 activity was inversely related to fatigue (p = 0.015) and tumor NE (p = 0.009), and was positively associated with vigor (p = 0.024). These findings suggest that psychological state and adrenergic signaling are linked with antioxidant enzyme activity in ovarian cancer and may have implications for patient treatments and outcomes.",
keywords = "Antioxidant enzymes, Biobehavioral, Neuroendocrine, Ovarian cancer, Stress",
author = "Bayer, {Jennifer L.} and Spitz, {Douglas R.} and Desire Christensen and McCormick, {Michael L.} and Donna Farley and {De Geest}, Koenraad and Laila Damoush and Samantha Aust and Sood, {Anil K.} and Lutgendorf, {Susan K.}",
year = "2015",
month = "1",
day = "11",
doi = "10.1016/j.bbi.2015.04.019",
language = "English (US)",
journal = "Brain, Behavior, and Immunity",
issn = "0889-1591",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma

AU - Bayer, Jennifer L.

AU - Spitz, Douglas R.

AU - Christensen, Desire

AU - McCormick, Michael L.

AU - Farley, Donna

AU - De Geest, Koenraad

AU - Damoush, Laila

AU - Aust, Samantha

AU - Sood, Anil K.

AU - Lutgendorf, Susan K.

PY - 2015/1/11

Y1 - 2015/1/11

N2 - Increased levels of reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide have been reported in many cancer cells and they have been implicated in carcinogenesis and tumor progression. Antioxidant enzymes, such as Manganese Superoxide Dismutase (MnSOD or SOD2) and Glutathione Peroxidase-1 (GPx1), act coordinately to neutralize ROS. These enzymes are also thought to contribute to cancer cell resistance to conventional radio-chemo-therapies. Although some relationships have been reported between psychosocial factors and the regulation of antioxidant enzymes, little is known about these relationships in the context of cancer progression.The current study investigated the levels of MnSOD and GPx1in confirmed serous, high-grade tumor tissue from 60 ovarian cancer patients, and explored the relationship between the activity of these enzymes, the levels of tumor norepinephrine (NE), and patient mood as determined via pre-operative questionnaires. MnSOD activity was positively related to depressed mood (p = 0.025) and tumor NE (p = 0.023). In contrast, GPx1 activity was inversely related to fatigue (p = 0.015) and tumor NE (p = 0.009), and was positively associated with vigor (p = 0.024). These findings suggest that psychological state and adrenergic signaling are linked with antioxidant enzyme activity in ovarian cancer and may have implications for patient treatments and outcomes.

AB - Increased levels of reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide have been reported in many cancer cells and they have been implicated in carcinogenesis and tumor progression. Antioxidant enzymes, such as Manganese Superoxide Dismutase (MnSOD or SOD2) and Glutathione Peroxidase-1 (GPx1), act coordinately to neutralize ROS. These enzymes are also thought to contribute to cancer cell resistance to conventional radio-chemo-therapies. Although some relationships have been reported between psychosocial factors and the regulation of antioxidant enzymes, little is known about these relationships in the context of cancer progression.The current study investigated the levels of MnSOD and GPx1in confirmed serous, high-grade tumor tissue from 60 ovarian cancer patients, and explored the relationship between the activity of these enzymes, the levels of tumor norepinephrine (NE), and patient mood as determined via pre-operative questionnaires. MnSOD activity was positively related to depressed mood (p = 0.025) and tumor NE (p = 0.023). In contrast, GPx1 activity was inversely related to fatigue (p = 0.015) and tumor NE (p = 0.009), and was positively associated with vigor (p = 0.024). These findings suggest that psychological state and adrenergic signaling are linked with antioxidant enzyme activity in ovarian cancer and may have implications for patient treatments and outcomes.

KW - Antioxidant enzymes

KW - Biobehavioral

KW - Neuroendocrine

KW - Ovarian cancer

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=84929692291&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929692291&partnerID=8YFLogxK

U2 - 10.1016/j.bbi.2015.04.019

DO - 10.1016/j.bbi.2015.04.019

M3 - Article

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

SN - 0889-1591

ER -