Bioactivatable derivatives of 8-substituted cAMP-analogues

Jens Kruppa, Stephen Keely, Frank Schwede, Carsten Schultz, Kim E. Barrett, Bernd Jastorff

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Four 8-substituted derivatives of cAMP were converted into their membrane-permeant acetoxymethyl esters (AM-esters). The activity of these bioactivatable compounds to induce chloride secretion of T84 cells was up to 100-fold increased compared to the non-modified cAMP derivatives.

Original languageEnglish (US)
Pages (from-to)945-948
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number7
DOIs
StatePublished - Apr 8 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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