Bioactivatable derivatives of 8-substituted cAMP-analogues

Jens Kruppa, Stephen Keely, Frank Schwede, Carsten Schultz, Kim E. Barrett, Bernd Jastorff

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Four 8-substituted derivatives of cAMP were converted into their membrane-permeant acetoxymethyl esters (AM-esters). The activity of these bioactivatable compounds to induce chloride secretion of T84 cells was up to 100-fold increased compared to the non-modified cAMP derivatives.

Original languageEnglish (US)
Pages (from-to)945-948
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number7
DOIs
StatePublished - Apr 8 1997
Externally publishedYes

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Chlorides
Esters
Derivatives
Membranes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Bioactivatable derivatives of 8-substituted cAMP-analogues. / Kruppa, Jens; Keely, Stephen; Schwede, Frank; Schultz, Carsten; Barrett, Kim E.; Jastorff, Bernd.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 7, 08.04.1997, p. 945-948.

Research output: Contribution to journalArticle

Kruppa, Jens ; Keely, Stephen ; Schwede, Frank ; Schultz, Carsten ; Barrett, Kim E. ; Jastorff, Bernd. / Bioactivatable derivatives of 8-substituted cAMP-analogues. In: Bioorganic and Medicinal Chemistry Letters. 1997 ; Vol. 7, No. 7. pp. 945-948.
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