Abstract
Four 8-substituted derivatives of cAMP were converted into their membrane-permeant acetoxymethyl esters (AM-esters). The activity of these bioactivatable compounds to induce chloride secretion of T84 cells was up to 100-fold increased compared to the non-modified cAMP derivatives.
Original language | English (US) |
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Pages (from-to) | 945-948 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 7 |
Issue number | 7 |
DOIs | |
State | Published - Apr 8 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry