Biliary atresia: Recent progress

Mikelle D. Bassett, Karen F. Murray

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations

Abstract

Extrahepatic biliary atresia (EHBA), an inflammatory sclerosing cholangiopathy, is the leading indication for liver transplantation in children. The cause is still unknown, although possible infectious, genetic, and immunologic etiologies have received much recent focus. These theories are often dependent on each other for secondary or coexisting mechanisms. Concern for EHBA is raised by a cholestatic infant, but the differential diagnosis is large and the path to diagnosis remains varied. Current treatment is surgical with an overall survival rate of approximately 90%. The goals of this article are to review the important clinical aspects of EHBA and to highlight some of the more recent scientific and clinical developments contributing to our understanding of this condition.

Original languageEnglish (US)
Pages (from-to)720-729
Number of pages10
JournalJournal of clinical gastroenterology
Volume42
Issue number6
DOIs
StatePublished - Jul 2008

Keywords

  • Biliary atresia
  • Chronic liver disease
  • Liver transplantation
  • Pediatrics
  • Portoenterostomy

ASJC Scopus subject areas

  • Gastroenterology

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