Bile metabolism and lithogenesis

Kathleen O'Connell, Karen Brasel

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Our understanding of bile metabolism and the molecular effects of bile acids has expanded in recent years. Bile acids, which are classically recognized for their involvement in dietary lipid absorption, are now known to be involved in many aspects of energy metabolism and disease processes in humans. Cholelithiasis, a consequence of altered bile metabolism, affects a significant number of American adults. An understanding of the disease process, risk factors, and complications of gallbladder disease is necessary for the development of novel targeted treatments and prophylactic therapies against the development of gallstones.

Original languageEnglish (US)
Pages (from-to)361-375
Number of pages15
JournalSurgical Clinics of North America
Volume94
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Bile Acids and Salts
Bile
Gallbladder Diseases
Cholelithiasis
Gallstones
Energy Metabolism
Lipids
Therapeutics

Keywords

  • Bile
  • Bile acids
  • Cholelithiasis
  • Gallbladder
  • Gallstones

ASJC Scopus subject areas

  • Surgery

Cite this

Bile metabolism and lithogenesis. / O'Connell, Kathleen; Brasel, Karen.

In: Surgical Clinics of North America, Vol. 94, No. 2, 2014, p. 361-375.

Research output: Contribution to journalArticle

O'Connell, Kathleen ; Brasel, Karen. / Bile metabolism and lithogenesis. In: Surgical Clinics of North America. 2014 ; Vol. 94, No. 2. pp. 361-375.
@article{3564525cd56f44c582a6ff3ad063a407,
title = "Bile metabolism and lithogenesis",
abstract = "Our understanding of bile metabolism and the molecular effects of bile acids has expanded in recent years. Bile acids, which are classically recognized for their involvement in dietary lipid absorption, are now known to be involved in many aspects of energy metabolism and disease processes in humans. Cholelithiasis, a consequence of altered bile metabolism, affects a significant number of American adults. An understanding of the disease process, risk factors, and complications of gallbladder disease is necessary for the development of novel targeted treatments and prophylactic therapies against the development of gallstones.",
keywords = "Bile, Bile acids, Cholelithiasis, Gallbladder, Gallstones",
author = "Kathleen O'Connell and Karen Brasel",
year = "2014",
doi = "10.1016/j.suc.2014.01.004",
language = "English (US)",
volume = "94",
pages = "361--375",
journal = "Surgical Clinics of North America",
issn = "0039-6109",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Bile metabolism and lithogenesis

AU - O'Connell, Kathleen

AU - Brasel, Karen

PY - 2014

Y1 - 2014

N2 - Our understanding of bile metabolism and the molecular effects of bile acids has expanded in recent years. Bile acids, which are classically recognized for their involvement in dietary lipid absorption, are now known to be involved in many aspects of energy metabolism and disease processes in humans. Cholelithiasis, a consequence of altered bile metabolism, affects a significant number of American adults. An understanding of the disease process, risk factors, and complications of gallbladder disease is necessary for the development of novel targeted treatments and prophylactic therapies against the development of gallstones.

AB - Our understanding of bile metabolism and the molecular effects of bile acids has expanded in recent years. Bile acids, which are classically recognized for their involvement in dietary lipid absorption, are now known to be involved in many aspects of energy metabolism and disease processes in humans. Cholelithiasis, a consequence of altered bile metabolism, affects a significant number of American adults. An understanding of the disease process, risk factors, and complications of gallbladder disease is necessary for the development of novel targeted treatments and prophylactic therapies against the development of gallstones.

KW - Bile

KW - Bile acids

KW - Cholelithiasis

KW - Gallbladder

KW - Gallstones

UR - http://www.scopus.com/inward/record.url?scp=84897116310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897116310&partnerID=8YFLogxK

U2 - 10.1016/j.suc.2014.01.004

DO - 10.1016/j.suc.2014.01.004

M3 - Article

VL - 94

SP - 361

EP - 375

JO - Surgical Clinics of North America

JF - Surgical Clinics of North America

SN - 0039-6109

IS - 2

ER -