Abstract
BACKGROUND: Gallbladder cancer (GBC) carries an unfavorable prognosis with high mortality. This retrospective study was conducted to identify prognostic factors after resection of GBC, to assist in selecting appropriate surgical and adjuvant therapy. METHODS: Sixty-two patients from two institutions were identified with GBC by pathology. In 25, the cancer was unresectable at presentation. The remaining 37 patients comprised the study population. Log-rank analysis was used to assess univariate association with disease-free survival (DFS) and disease-specific survival (DSS). Cox regression was used for multivariate analysis. RESULTS: Median DFS and DSS were 22.6 and 28.5 months respectively, with a median follow-up of 44.2 months. On univariate analysis, bile duct (BD) involvement was significantly associated with decreased DFS (P ≤.001) and DSS (P =.004). BD involvement was uniformly fatal. LN involvement was not significantly associated with DFS or DSS (P =.85, P =.54). CONCLUSIONS: All patients with BD involvement in our population died of the disease. The subset of patients with resectable GBC and BD involvement is a group that is at high risk for recurrence and should be treated as such. In our small population, preoperative and intraoperative methods evaluating BD involvement were unreliable.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 101-105 |
| Number of pages | 5 |
| Journal | Gastrointestinal Cancer Research |
| Volume | 6 |
| Issue number | 4 |
| State | Published - Jul 2013 |
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ASJC Scopus subject areas
- Oncology
- Gastroenterology
Cite this
Bile duct involvement portends poor prognosis in resected gallbladder carcinoma. / Eil, Robert; Hansen, Paul D.; Cassera, Maria; Orloff, Susan; Sheppard, Brett; Diggs, Brian; Billingsley, Kevin.
In: Gastrointestinal Cancer Research, Vol. 6, No. 4, 07.2013, p. 101-105.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bile duct involvement portends poor prognosis in resected gallbladder carcinoma
AU - Eil, Robert
AU - Hansen, Paul D.
AU - Cassera, Maria
AU - Orloff, Susan
AU - Sheppard, Brett
AU - Diggs, Brian
AU - Billingsley, Kevin
PY - 2013/7
Y1 - 2013/7
N2 - BACKGROUND: Gallbladder cancer (GBC) carries an unfavorable prognosis with high mortality. This retrospective study was conducted to identify prognostic factors after resection of GBC, to assist in selecting appropriate surgical and adjuvant therapy. METHODS: Sixty-two patients from two institutions were identified with GBC by pathology. In 25, the cancer was unresectable at presentation. The remaining 37 patients comprised the study population. Log-rank analysis was used to assess univariate association with disease-free survival (DFS) and disease-specific survival (DSS). Cox regression was used for multivariate analysis. RESULTS: Median DFS and DSS were 22.6 and 28.5 months respectively, with a median follow-up of 44.2 months. On univariate analysis, bile duct (BD) involvement was significantly associated with decreased DFS (P ≤.001) and DSS (P =.004). BD involvement was uniformly fatal. LN involvement was not significantly associated with DFS or DSS (P =.85, P =.54). CONCLUSIONS: All patients with BD involvement in our population died of the disease. The subset of patients with resectable GBC and BD involvement is a group that is at high risk for recurrence and should be treated as such. In our small population, preoperative and intraoperative methods evaluating BD involvement were unreliable.
AB - BACKGROUND: Gallbladder cancer (GBC) carries an unfavorable prognosis with high mortality. This retrospective study was conducted to identify prognostic factors after resection of GBC, to assist in selecting appropriate surgical and adjuvant therapy. METHODS: Sixty-two patients from two institutions were identified with GBC by pathology. In 25, the cancer was unresectable at presentation. The remaining 37 patients comprised the study population. Log-rank analysis was used to assess univariate association with disease-free survival (DFS) and disease-specific survival (DSS). Cox regression was used for multivariate analysis. RESULTS: Median DFS and DSS were 22.6 and 28.5 months respectively, with a median follow-up of 44.2 months. On univariate analysis, bile duct (BD) involvement was significantly associated with decreased DFS (P ≤.001) and DSS (P =.004). BD involvement was uniformly fatal. LN involvement was not significantly associated with DFS or DSS (P =.85, P =.54). CONCLUSIONS: All patients with BD involvement in our population died of the disease. The subset of patients with resectable GBC and BD involvement is a group that is at high risk for recurrence and should be treated as such. In our small population, preoperative and intraoperative methods evaluating BD involvement were unreliable.
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M3 - Article
VL - 6
SP - 101
EP - 105
JO - Gastrointestinal Cancer Research
JF - Gastrointestinal Cancer Research
SN - 1934-7820
IS - 4
ER -