Bile duct involvement portends poor prognosis in resected gallbladder carcinoma

Robert Eil, Paul D. Hansen, Maria Cassera, Susan Orloff, Brett Sheppard, Brian Diggs, Kevin Billingsley

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND: Gallbladder cancer (GBC) carries an unfavorable prognosis with high mortality. This retrospective study was conducted to identify prognostic factors after resection of GBC, to assist in selecting appropriate surgical and adjuvant therapy. METHODS: Sixty-two patients from two institutions were identified with GBC by pathology. In 25, the cancer was unresectable at presentation. The remaining 37 patients comprised the study population. Log-rank analysis was used to assess univariate association with disease-free survival (DFS) and disease-specific survival (DSS). Cox regression was used for multivariate analysis. RESULTS: Median DFS and DSS were 22.6 and 28.5 months respectively, with a median follow-up of 44.2 months. On univariate analysis, bile duct (BD) involvement was significantly associated with decreased DFS (P ≤.001) and DSS (P =.004). BD involvement was uniformly fatal. LN involvement was not significantly associated with DFS or DSS (P =.85, P =.54). CONCLUSIONS: All patients with BD involvement in our population died of the disease. The subset of patients with resectable GBC and BD involvement is a group that is at high risk for recurrence and should be treated as such. In our small population, preoperative and intraoperative methods evaluating BD involvement were unreliable.

Original languageEnglish (US)
Pages (from-to)101-105
Number of pages5
JournalGastrointestinal Cancer Research
Volume6
Issue number4
StatePublished - Jul 2013

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Gallbladder Neoplasms
Bile Ducts
Gallbladder
Disease-Free Survival
Carcinoma
Survival
Bile Duct Neoplasms
Population
Multivariate Analysis
Retrospective Studies
Pathology
Recurrence
Mortality
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

Bile duct involvement portends poor prognosis in resected gallbladder carcinoma. / Eil, Robert; Hansen, Paul D.; Cassera, Maria; Orloff, Susan; Sheppard, Brett; Diggs, Brian; Billingsley, Kevin.

In: Gastrointestinal Cancer Research, Vol. 6, No. 4, 07.2013, p. 101-105.

Research output: Contribution to journalArticle

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AU - Diggs, Brian

AU - Billingsley, Kevin

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N2 - BACKGROUND: Gallbladder cancer (GBC) carries an unfavorable prognosis with high mortality. This retrospective study was conducted to identify prognostic factors after resection of GBC, to assist in selecting appropriate surgical and adjuvant therapy. METHODS: Sixty-two patients from two institutions were identified with GBC by pathology. In 25, the cancer was unresectable at presentation. The remaining 37 patients comprised the study population. Log-rank analysis was used to assess univariate association with disease-free survival (DFS) and disease-specific survival (DSS). Cox regression was used for multivariate analysis. RESULTS: Median DFS and DSS were 22.6 and 28.5 months respectively, with a median follow-up of 44.2 months. On univariate analysis, bile duct (BD) involvement was significantly associated with decreased DFS (P ≤.001) and DSS (P =.004). BD involvement was uniformly fatal. LN involvement was not significantly associated with DFS or DSS (P =.85, P =.54). CONCLUSIONS: All patients with BD involvement in our population died of the disease. The subset of patients with resectable GBC and BD involvement is a group that is at high risk for recurrence and should be treated as such. In our small population, preoperative and intraoperative methods evaluating BD involvement were unreliable.

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