Bilateral uveitis manifesting as a complication of chronic graft-versus-host disease after allogeneic bone marrow transplantation

Michael Wertheim, James (Jim) Rosenbaum

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: To document the rare occurrence of uveitis presumed secondary to chronic graft-versus-host disease (cGVHD). Methods: Observational case report. Results: A 52-year-old Filipino male who had undergone allogeneic BMT 10 years earlier presented with bilateral uveitis and biopsy-proven cutaneous cGVHD. There was no evidence of infection or other immune-related causes and the inflammation had a temporal correlation with his dermatological GVHD. The patient responded to treatment with oral cyclosporin A. Conclusion: The coexistence of uveitis and cGVHD is rare. The ophthalmologist should be aware of such an association and work together with the oncologist to treat these patients appropriately.

Original languageEnglish (US)
Pages (from-to)403-404
Number of pages2
JournalOcular Immunology and Inflammation
Volume13
Issue number5
DOIs
StatePublished - Oct 2005

Fingerprint

Uveitis
Homologous Transplantation
Graft vs Host Disease
Bone Marrow Transplantation
Cyclosporine
Inflammation
Biopsy
Skin
Infection
Therapeutics

Keywords

  • Allogeneic
  • Bone marrow transplant
  • Graft-versus-host
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy

Cite this

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abstract = "Purpose: To document the rare occurrence of uveitis presumed secondary to chronic graft-versus-host disease (cGVHD). Methods: Observational case report. Results: A 52-year-old Filipino male who had undergone allogeneic BMT 10 years earlier presented with bilateral uveitis and biopsy-proven cutaneous cGVHD. There was no evidence of infection or other immune-related causes and the inflammation had a temporal correlation with his dermatological GVHD. The patient responded to treatment with oral cyclosporin A. Conclusion: The coexistence of uveitis and cGVHD is rare. The ophthalmologist should be aware of such an association and work together with the oncologist to treat these patients appropriately.",
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AU - Wertheim, Michael

AU - Rosenbaum, James (Jim)

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N2 - Purpose: To document the rare occurrence of uveitis presumed secondary to chronic graft-versus-host disease (cGVHD). Methods: Observational case report. Results: A 52-year-old Filipino male who had undergone allogeneic BMT 10 years earlier presented with bilateral uveitis and biopsy-proven cutaneous cGVHD. There was no evidence of infection or other immune-related causes and the inflammation had a temporal correlation with his dermatological GVHD. The patient responded to treatment with oral cyclosporin A. Conclusion: The coexistence of uveitis and cGVHD is rare. The ophthalmologist should be aware of such an association and work together with the oncologist to treat these patients appropriately.

AB - Purpose: To document the rare occurrence of uveitis presumed secondary to chronic graft-versus-host disease (cGVHD). Methods: Observational case report. Results: A 52-year-old Filipino male who had undergone allogeneic BMT 10 years earlier presented with bilateral uveitis and biopsy-proven cutaneous cGVHD. There was no evidence of infection or other immune-related causes and the inflammation had a temporal correlation with his dermatological GVHD. The patient responded to treatment with oral cyclosporin A. Conclusion: The coexistence of uveitis and cGVHD is rare. The ophthalmologist should be aware of such an association and work together with the oncologist to treat these patients appropriately.

KW - Allogeneic

KW - Bone marrow transplant

KW - Graft-versus-host

KW - Uveitis

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