Bilateral uveitis in a patient with autoimmune lymphoproliferative syndrome

Wee Kiak Lim, Roxana Ursea, Koneti Rao, Ronald R. Buggage, Eric B. Suhler, Faith Dugan, Chi Chao Chan, Stephen E. Straus, Robert B. Nussenblatt

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

PURPOSE: We report a case of autoimmune lymphoproliferative syndrome (ALPS) presenting with bilateral uveitis. DESIGN: Observational case report. METHODS: Review of case record, serum and aqueous IL-10 and IL-6 cytokine results, and immunosuppressive treatment of a patient with a mutation in the gene encoding Fas. RESULTS: Control of the intermediate uveitis required sustained doses of topical and periocular corticosteroids as well as systemic cyclosporine. The serum IL-10 level was elevated, as commonly seen in ALPS, but the aqueous IL-10 was not. CONCLUSIONS: Despite a Th2 immune predominance in ALPS, uveitis, a Th1-mediated disease, may still manifest in these patients. The pathogenesis of uveitis in ALPS may differ from that of the systemic disease overall. Long-term follow-up is required for patients with uveitis associated with ALPS.

Original languageEnglish (US)
Pages (from-to)562-563
Number of pages2
JournalAmerican journal of ophthalmology
Volume139
Issue number3
DOIs
StatePublished - Mar 2005

ASJC Scopus subject areas

  • Ophthalmology

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    Lim, W. K., Ursea, R., Rao, K., Buggage, R. R., Suhler, E. B., Dugan, F., Chan, C. C., Straus, S. E., & Nussenblatt, R. B. (2005). Bilateral uveitis in a patient with autoimmune lymphoproliferative syndrome. American journal of ophthalmology, 139(3), 562-563. https://doi.org/10.1016/j.ajo.2004.09.017