Bilateral paraneoplastic optic neuropathy and unilateral retinal compromise in association with prostate cancer: A differential diagnostic challenge in a patient with unexplained visual loss

Giovannella Carboni, Gina Forma, April D. Bond, Grazyna Adamus, Alessandro Iannaccone

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We report a 77-year-old Caucasian man with a 1-year complaint of unexplained visual loss and a 4-year history of prostate cancer. A complete ophthalmologic exam, Goldmann visual fields (GVFs), intravenous fluorescein angiography (IVFA), macular and disc optical coherence tomography (OCT), pattern-reversal visual evoked potentials (PVEPs), and flash electroretinograms (ERGs) were performed. On examination, visual acuity was reduced bilaterally. Fundus exam showed juxtapapillary changes (OS > OD) and, in OS, disc pallor, peripheral RPE dropout and whitish retinal discoloration along the arcades. OCTs were normal OU. Cancer-associated retinopathy (CAR) was suspected. A flash ERG was normal OD and markedly reduced and electronegative OS. An IVFA showed bilateral juxtapapillary staining and changes highly suggestive of sequelae of central retinal artery occlusion (CRAO) OS, in which a cilioretinal artery existed along the papillomacular bundle. GVFs showed bilateral blind spot enlargement and centrocecal scotomas, and PVEPs were delayed. These findings suggested cancer-associated optic neuropathy (CAON), confirmed by presence of anti-optic nerve autoantibodies (auto-Abs). No anti-retinal auto-Abs were found. CAON is a less common paraneoplastic manifestation than CAR and it is rarely observed in association with prostate cancer. A combination of visual function testing methods permitted the recognition, in this highly unusual case, of the concurrent presence of unilateral ERG changes most likely attributable to CRAO complications in OS, in all likelihood unrelated to CAON, and not to be confused with unilateral CAR. Auto-Ab testing in combination with visual function tests helps achieve a better understanding of the pathophysiology of vision loss in paraneoplastic visual syndromes.

Original languageEnglish (US)
Pages (from-to)63-70
Number of pages8
JournalDocumenta Ophthalmologica
Volume125
Issue number1
DOIs
StatePublished - Aug 2012

Fingerprint

Paraneoplastic Polyneuropathy
Ocular Paraneoplastic Syndromes
Optic Nerve Diseases
Retinal Artery Occlusion
Prostatic Neoplasms
Visual Evoked Potentials
Fluorescein Angiography
Pallor
Scotoma
Paraneoplastic Syndromes
Neoplasms
Visual Field Tests
Optic Disk
Optical Coherence Tomography
Optic Nerve
Visual Fields
Autoantibodies
Visual Acuity
Arteries
Staining and Labeling

Keywords

  • Autoimmunity
  • Central retinal artery occlusion
  • Electroretinogram
  • Paraneoplastic optic neuropathy
  • Visual evoked potentials
  • Visual field

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Physiology (medical)

Cite this

Bilateral paraneoplastic optic neuropathy and unilateral retinal compromise in association with prostate cancer : A differential diagnostic challenge in a patient with unexplained visual loss. / Carboni, Giovannella; Forma, Gina; Bond, April D.; Adamus, Grazyna; Iannaccone, Alessandro.

In: Documenta Ophthalmologica, Vol. 125, No. 1, 08.2012, p. 63-70.

Research output: Contribution to journalArticle

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