TY - JOUR
T1 - Bilateral ovarian carcinoma
T2 - Cytogenetic evidence of unicentric origin
AU - Pejovic, Tanja
AU - Heim, Sverre
AU - Mandahl, Nils
AU - Elmfors, Bengt
AU - Furgyik, Stefan
AU - Flodérus, Ulla‐Maria ‐M
AU - Helm, GÖRan
AU - Willén, Helena
AU - Mitelman, Felix
PY - 1991/2/1
Y1 - 1991/2/1
N2 - Cytogenetic analyses were performed on the tumors from both ovaries in 15 patients with bilateral ovarian carcinoma. In 4 of them, omental implants were also examined. Abnormal karyotypes were detected in 11 cases. The baseline karyotypes in the 2 tumorous ovaries were identical in each patient, indicating that bilateral ovarian cancer develops by metastatic spreading. There was no clear‐cut evidence of differences in the clonal evolution between the tumors of the 2 ovaries, and hence the side harboring the primary tumor could never be determined. The metastatic nature of the omental implants was proved by the fact that their karyotypes were indistinguishable from those of the ovarian tumor tissue.
AB - Cytogenetic analyses were performed on the tumors from both ovaries in 15 patients with bilateral ovarian carcinoma. In 4 of them, omental implants were also examined. Abnormal karyotypes were detected in 11 cases. The baseline karyotypes in the 2 tumorous ovaries were identical in each patient, indicating that bilateral ovarian cancer develops by metastatic spreading. There was no clear‐cut evidence of differences in the clonal evolution between the tumors of the 2 ovaries, and hence the side harboring the primary tumor could never be determined. The metastatic nature of the omental implants was proved by the fact that their karyotypes were indistinguishable from those of the ovarian tumor tissue.
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U2 - 10.1002/ijc.2910470308
DO - 10.1002/ijc.2910470308
M3 - Article
C2 - 1993543
AN - SCOPUS:0026012867
SN - 0020-7136
VL - 47
SP - 358
EP - 361
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 3
ER -