TY - JOUR
T1 - Bilateral herpes simplex virus type 2 keratitis
T2 - a clinicopathologic report with immunohistochemical and ultrastructural observations.
AU - Rummelt, V.
AU - Folberg, R.
AU - Rummelt, C.
AU - Palay, D. A.
AU - Mathers, W. D.
AU - Parys-van Ginderdeuren, R.
AU - Krachmer, J. H.
AU - Yi, H.
PY - 1995/3
Y1 - 1995/3
N2 - This report describes the clinical, histopathologic, ultrastructural, and immunohistochemical findings in two corneal buttons from a 13-year-old girl who developed bilateral progressive corneal stromal opacification during childhood. As determined by light microscopy, both corneal buttons were edematous with a chronic inflammatory infiltrate confined to the deep layers of the stroma. We detected intranuclear eosinophilic inclusions in some epithelial cells. We detected herpesvirus particles in stromal keratocytes and endothelial cells by transmission electron microscopy. Immunohistochemistry studies identified concurrent expression of specific herpes simplex virus type 2 antigen in corneal epithelial cells, in keratocytes in the deep layers of the stroma, and in endothelial cells. The cause of progressive bilateral stromal corneal opacification in this child was herpes simplex virus type 2 keratitis. This condition should be considered in the differential diagnosis of progressive, bilateral corneal opacification in children.
AB - This report describes the clinical, histopathologic, ultrastructural, and immunohistochemical findings in two corneal buttons from a 13-year-old girl who developed bilateral progressive corneal stromal opacification during childhood. As determined by light microscopy, both corneal buttons were edematous with a chronic inflammatory infiltrate confined to the deep layers of the stroma. We detected intranuclear eosinophilic inclusions in some epithelial cells. We detected herpesvirus particles in stromal keratocytes and endothelial cells by transmission electron microscopy. Immunohistochemistry studies identified concurrent expression of specific herpes simplex virus type 2 antigen in corneal epithelial cells, in keratocytes in the deep layers of the stroma, and in endothelial cells. The cause of progressive bilateral stromal corneal opacification in this child was herpes simplex virus type 2 keratitis. This condition should be considered in the differential diagnosis of progressive, bilateral corneal opacification in children.
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M3 - Article
C2 - 7795510
AN - SCOPUS:0029267802
SN - 0941-2921
VL - 4
SP - 116
EP - 122
JO - German journal of ophthalmology
JF - German journal of ophthalmology
IS - 2
ER -