Bilateral herpes simplex virus type 2 keratitis: a clinicopathologic report with immunohistochemical and ultrastructural observations.

V. Rummelt, R. Folberg, C. Rummelt, D. A. Palay, William Mathers, R. Parys-van Ginderdeuren, J. H. Krachmer, H. Yi

Research output: Contribution to journalArticle

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Abstract

This report describes the clinical, histopathologic, ultrastructural, and immunohistochemical findings in two corneal buttons from a 13-year-old girl who developed bilateral progressive corneal stromal opacification during childhood. As determined by light microscopy, both corneal buttons were edematous with a chronic inflammatory infiltrate confined to the deep layers of the stroma. We detected intranuclear eosinophilic inclusions in some epithelial cells. We detected herpesvirus particles in stromal keratocytes and endothelial cells by transmission electron microscopy. Immunohistochemistry studies identified concurrent expression of specific herpes simplex virus type 2 antigen in corneal epithelial cells, in keratocytes in the deep layers of the stroma, and in endothelial cells. The cause of progressive bilateral stromal corneal opacification in this child was herpes simplex virus type 2 keratitis. This condition should be considered in the differential diagnosis of progressive, bilateral corneal opacification in children.

Original languageEnglish (US)
Pages (from-to)116-122
Number of pages7
JournalGerman journal of ophthalmology
Volume4
Issue number2
StatePublished - Mar 1995
Externally publishedYes

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Human Herpesvirus 2
Keratitis
Endothelial Cells
Epithelial Cells
Intranuclear Inclusion Bodies
Herpesviridae
Stromal Cells
Transmission Electron Microscopy
Microscopy
Differential Diagnosis
Cohort Studies
Immunohistochemistry
Light
Antigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bilateral herpes simplex virus type 2 keratitis : a clinicopathologic report with immunohistochemical and ultrastructural observations. / Rummelt, V.; Folberg, R.; Rummelt, C.; Palay, D. A.; Mathers, William; Parys-van Ginderdeuren, R.; Krachmer, J. H.; Yi, H.

In: German journal of ophthalmology, Vol. 4, No. 2, 03.1995, p. 116-122.

Research output: Contribution to journalArticle

Rummelt, V, Folberg, R, Rummelt, C, Palay, DA, Mathers, W, Parys-van Ginderdeuren, R, Krachmer, JH & Yi, H 1995, 'Bilateral herpes simplex virus type 2 keratitis: a clinicopathologic report with immunohistochemical and ultrastructural observations.', German journal of ophthalmology, vol. 4, no. 2, pp. 116-122.
Rummelt, V. ; Folberg, R. ; Rummelt, C. ; Palay, D. A. ; Mathers, William ; Parys-van Ginderdeuren, R. ; Krachmer, J. H. ; Yi, H. / Bilateral herpes simplex virus type 2 keratitis : a clinicopathologic report with immunohistochemical and ultrastructural observations. In: German journal of ophthalmology. 1995 ; Vol. 4, No. 2. pp. 116-122.
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