Big bottlenecks in cardiovascular tissue engineering

Ngan F. Huang, Vahid Serpooshan, Viola B. Morris, Nazish Sayed, Gaspard Pardon, Oscar J. Abilez, Karina H. Nakayama, Beth L. Pruitt, Sean M. Wu, Young sup Yoon, Jianyi Zhang, Joseph C. Wu

Research output: Contribution to journalComment/debatepeer-review

19 Scopus citations

Abstract

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

Original languageEnglish (US)
Article number199
JournalCommunications Biology
Volume1
Issue number1
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Medicine (miscellaneous)

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