Beyond tumor necrosis factor inhibition: The expanding pipeline of biologic therapies for inflammatory diseases and their associated infectious sequelae

S. A. Novosad, Kevin Winthrop

Research output: Contribution to journalArticle

28 Scopus citations


Patients with rheumatoid arthritis and other immune-mediated inflammatory diseases are at higher risk for infectious morbidity and mortality, partially due to the therapies used to treat these conditions. Both prednisone and targeted biologic therapies such as tumor necrosis factor antagonists have been implicated to various degrees, although in some cases firm data are lacking with regard to certain types of infections. To date, there is a paucity of information regarding the infectious risks associated with the newer biologic agents. As new biologic agents become available for use, their potential infectious risks will challenge infectious disease clinicians who must work to prevent, diagnose, and treat infections in this setting. This article reviews our current understanding of infectious risk in the setting of targeted therapies and provides an update of the immune system targets and potential infectious sequelae of both current and emerging biologic therapies.

Original languageEnglish (US)
Pages (from-to)1587-1598
Number of pages12
JournalClinical Infectious Diseases
Issue number11
Publication statusPublished - Jun 1 2014



  • Anti-TNF agents
  • Autoimmune disease
  • Biologic therapies
  • Infection
  • Opportunistic infections

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Medicine(all)

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