Beyond red hair and sunburns: Uncovering the molecular mechanisms of MC1R signaling and repair of UV-induced DNA damage

Pamela B. Cassidy, Zalfa A. Abdel-Malek, Sancy A. Leachman

Research output: Contribution to journalComment/debate

7 Scopus citations

Abstract

Scientists at the University of Kentucky are unraveling the details of DNA-damage repair in the melanocyte, with an eye towards finding druggable targets for melanoma prevention. Jarret et al., (2015, this issue) report in this issue three new assays that can yield mechanistic information about nucleotide excision repair (NER) stimulated by cAMP-dependent signaling downstream of the melanocortin-1 receptor (MC1R).

Original languageEnglish (US)
Pages (from-to)2918-2921
Number of pages4
JournalJournal of Investigative Dermatology
Volume135
Issue number12
DOIs
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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