Better adherence with once-daily antiretroviral regimens: A meta-analysis

Jean Jacques Parienti; David R. Bangsberg; Renaud Verdon; Edward M. Gardner

doi:10.1086/596482

Better adherence with once-daily antiretroviral regimens: A meta-analysis

Jean Jacques Parienti, David R. Bangsberg, Renaud Verdon, Edward M. Gardner

Research output: Contribution to journal › Article › peer-review

205 Scopus citations

Abstract

Once-daily regimens of antiretroviral therapy are simpler than other regimens, but whether such regimens are associated with better adherence to treatment is controversial. We performed a meta-analysis of 11 randomized, controlled trials (total number of subjects, 3029), which revealed that the adherence rate was better with once-daily regimens (+2.9%; 95% confidence interval, 1.0%-4.8%; P < .003) than with twice-daily regimens. This modest effect was more pronounced at the time of treatment initiation and for regimens for which all medications were taken once per day.

Original language	English (US)
Pages (from-to)	484-488
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	48
Issue number	4
DOIs	https://doi.org/10.1086/596482
State	Published - Feb 15 2009
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1086/596482

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title = "Better adherence with once-daily antiretroviral regimens: A meta-analysis",

abstract = "Once-daily regimens of antiretroviral therapy are simpler than other regimens, but whether such regimens are associated with better adherence to treatment is controversial. We performed a meta-analysis of 11 randomized, controlled trials (total number of subjects, 3029), which revealed that the adherence rate was better with once-daily regimens (+2.9%; 95% confidence interval, 1.0%-4.8%; P < .003) than with twice-daily regimens. This modest effect was more pronounced at the time of treatment initiation and for regimens for which all medications were taken once per day.",

author = "Parienti, {Jean Jacques} and Bangsberg, {David R.} and Renaud Verdon and Gardner, {Edward M.}",

note = "Funding Information: Potential conflicts of interest. J.-J.P. has received prior grant support from Abbott and Boehringer-Ingelheim. D.R.B. has received prior grant support from Abbott, Bristol-Myers Squibb, and Gilead Sciences. R.V. and E.M.G.: no conflicts. Funding Information: Financial support. C{\^o}te de Nacre University Hospital (research grant to J.-J.P.), National Institute of Alcohol Abuse and Alcoholism (K-24 015287 to E.M.G.) and the National Institutes of Health (career development award AI067063 to D.R.B.).",

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AU - Bangsberg, David R.

AU - Verdon, Renaud

AU - Gardner, Edward M.

N1 - Funding Information: Potential conflicts of interest. J.-J.P. has received prior grant support from Abbott and Boehringer-Ingelheim. D.R.B. has received prior grant support from Abbott, Bristol-Myers Squibb, and Gilead Sciences. R.V. and E.M.G.: no conflicts. Funding Information: Financial support. Côte de Nacre University Hospital (research grant to J.-J.P.), National Institute of Alcohol Abuse and Alcoholism (K-24 015287 to E.M.G.) and the National Institutes of Health (career development award AI067063 to D.R.B.).

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Better adherence with once-daily antiretroviral regimens: A meta-analysis

Abstract

ASJC Scopus subject areas

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