Betahistine-induced vascular effects in the rat cochlea

E. A. Laurikainen, J. M. Miller, W. S. Quirk, J. Kallinen, Tianying Ren, Alfred Nuttall, R. Grenman, E. Virolainen

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Betahistine (BH) has been used widely to treat cochlear disorders, such as tinnitus and Meniere's disease. The mechanism of action of BH in the cochlea is assumed to be based on its histamine-like effect on H1 receptors in the cochlear vasculature, leading to an increased cochlear blood flow (CBF). Recently it has been shown that BH can strongly affect H3 heteroreceptors (a novel histamine receptor subclass) in the periphery, via an autonomic ligand. This mechanism may also contribute to the BH effects on CBF. This study was to validate BH effects in the cochlear vasculature and to investigate the possible mechanisms of action of this drug in the inner ear vasculature. We assessed the effects of BH on CBF with the laser Doppler flowmeter in 23 rats and concluded that BH affects vascular conductivity in the cochlea in a dose-dependent fashion; betahistine diffuses through the round window, but does not have access to vascular receptors or ligands once in the labyrinthine fluids; and the H1 receptors mediate the systemic and peripheral vascular effects of BH, whereas the cochlear effect involves cholinergic receptors.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalAmerican Journal of Otology
Volume14
Issue number1
StatePublished - 1993
Externally publishedYes

Fingerprint

Betahistine
Cochlea
Blood Vessels
Histamine H1 Receptors
Labyrinthine Fluids
Histamine Agents
Ligands
Histamine Receptors
Flowmeters
Meniere Disease
Tinnitus
Cholinergic Receptors
Inner Ear
Lasers

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Laurikainen, E. A., Miller, J. M., Quirk, W. S., Kallinen, J., Ren, T., Nuttall, A., ... Virolainen, E. (1993). Betahistine-induced vascular effects in the rat cochlea. American Journal of Otology, 14(1), 24-30.

Betahistine-induced vascular effects in the rat cochlea. / Laurikainen, E. A.; Miller, J. M.; Quirk, W. S.; Kallinen, J.; Ren, Tianying; Nuttall, Alfred; Grenman, R.; Virolainen, E.

In: American Journal of Otology, Vol. 14, No. 1, 1993, p. 24-30.

Research output: Contribution to journalArticle

Laurikainen, EA, Miller, JM, Quirk, WS, Kallinen, J, Ren, T, Nuttall, A, Grenman, R & Virolainen, E 1993, 'Betahistine-induced vascular effects in the rat cochlea', American Journal of Otology, vol. 14, no. 1, pp. 24-30.
Laurikainen EA, Miller JM, Quirk WS, Kallinen J, Ren T, Nuttall A et al. Betahistine-induced vascular effects in the rat cochlea. American Journal of Otology. 1993;14(1):24-30.
Laurikainen, E. A. ; Miller, J. M. ; Quirk, W. S. ; Kallinen, J. ; Ren, Tianying ; Nuttall, Alfred ; Grenman, R. ; Virolainen, E. / Betahistine-induced vascular effects in the rat cochlea. In: American Journal of Otology. 1993 ; Vol. 14, No. 1. pp. 24-30.
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