Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro

Molly Kulesz-Martin, Remedios Penetrante, Christopher J. East

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Stable pre-tumorigenic, benign tumor and squamous cell carcinoma stages have been isolated after treatment of a cloned mouse keratinocyte line with 7,12-dimethylbenz[a]anthracene. Intraperitoneal injection and skin grafting of athymic nude mice were suitable for growth of these well-differentiated tumor cells, whereas subcutaneous injection was not.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalCarcinogenesis
Volume9
Issue number1
DOIs
StatePublished - Jan 1988
Externally publishedYes

Fingerprint

Anthracene
Keratinocytes
Nude Mice
Mouse
Tumors
Tumor
Injection
Skin Transplantation
Line
Cell
Subcutaneous Injections
Intraperitoneal Injections
Skin
Squamous Cell Carcinoma
Neoplasms
Cells
Growth
anthracene
In Vitro Techniques
Therapeutics

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience
  • Cancer Research

Cite this

Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro. / Kulesz-Martin, Molly; Penetrante, Remedios; East, Christopher J.

In: Carcinogenesis, Vol. 9, No. 1, 01.1988, p. 171-174.

Research output: Contribution to journalArticle

@article{169e5f3f57974763961588e5dadac598,
title = "Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro",
abstract = "Stable pre-tumorigenic, benign tumor and squamous cell carcinoma stages have been isolated after treatment of a cloned mouse keratinocyte line with 7,12-dimethylbenz[a]anthracene. Intraperitoneal injection and skin grafting of athymic nude mice were suitable for growth of these well-differentiated tumor cells, whereas subcutaneous injection was not.",
author = "Molly Kulesz-Martin and Remedios Penetrante and East, {Christopher J.}",
year = "1988",
month = "1",
doi = "10.1093/carcin/9.1.171",
language = "English (US)",
volume = "9",
pages = "171--174",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Benign and malignant tumor stages in a mouse keratinocyte line treated with 7,12-dimethylbenz[a]anthracene in vitro

AU - Kulesz-Martin, Molly

AU - Penetrante, Remedios

AU - East, Christopher J.

PY - 1988/1

Y1 - 1988/1

N2 - Stable pre-tumorigenic, benign tumor and squamous cell carcinoma stages have been isolated after treatment of a cloned mouse keratinocyte line with 7,12-dimethylbenz[a]anthracene. Intraperitoneal injection and skin grafting of athymic nude mice were suitable for growth of these well-differentiated tumor cells, whereas subcutaneous injection was not.

AB - Stable pre-tumorigenic, benign tumor and squamous cell carcinoma stages have been isolated after treatment of a cloned mouse keratinocyte line with 7,12-dimethylbenz[a]anthracene. Intraperitoneal injection and skin grafting of athymic nude mice were suitable for growth of these well-differentiated tumor cells, whereas subcutaneous injection was not.

UR - http://www.scopus.com/inward/record.url?scp=0013664647&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013664647&partnerID=8YFLogxK

U2 - 10.1093/carcin/9.1.171

DO - 10.1093/carcin/9.1.171

M3 - Article

C2 - 2446796

AN - SCOPUS:0013664647

VL - 9

SP - 171

EP - 174

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 1

ER -