Beneficial effect of pre-transplant splenectomy for leukopenia in primary cadaver kidney transplants

John Barry, B. Larson, S. M. Fischer, Douglas Norman, W. M. Bennett

Research output: Contribution to journalArticle


Pre-transplant splenectomy is controversial. We compared 21 nondiabetic, transfused recipients of first cadaver kidney grafts who underwent pre-transplant splenectomy for steroid-resistant leukopenia to 114 without steroid-resistant leukopenia. Kidney graft survivals at 2 years were 80.2 plus or minus 8.9 and 48.5 plus or minus 5.3 per cent, respectively (p <0.05). The 2-year actuarial patient survivals were not significantly different (89.6 plus or minus 7.0 versus 87.8 plus or minus 3.9 per cent). Azathioprine doses and serum creatinine levels at 1 year were not significantly different. Pretransplant splenectomy for steroid-resistant leukopenia resulted in a significant decrease in kidney graft losses owing to rejection without an increased risk of death of sepsis or thromboembolism.

Original languageEnglish (US)
Pages (from-to)479-480
Number of pages2
JournalJournal of Urology
Issue number3
Publication statusPublished - 1983


ASJC Scopus subject areas

  • Urology

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