TY - JOUR
T1 - Behavioural testing of standard inbred and 5HT1B knockout mice
T2 - Implications of absent corpus callosum
AU - Wahlsten, Douglas
AU - Crabbe, John C.
AU - Dudek, Bruce C.
N1 - Funding Information:
Portions of the work reported in this paper were supported by research grants to DW from NSERC and NIAAA and to JCC from NIAAA and the Office of Behavioral and Social Science Research at NIH. The authors are grateful to P. Melike Schalomon, Pam Metten, and Jason Sibert for expert technical assistance.
PY - 2001/11/8
Y1 - 2001/11/8
N2 - Rapid advances in biotechnology have created new demands for tests of mouse behaviour having both high reliability and high throughput for mass screening. This paper discusses several statistical and psychological factors pertinent to replication of results in different laboratories, and it considers the question of which inbred strains are best for test standardization. In this context, the problem of absent corpus callosum in the 129 strains is addressed with data from a recent study of six diverse tests of behaviour, and it is shown that effects of absent corpus callosum are usually nonsignificant and/or very small. Whether any 129 substrain is to be included in the list of standard strains depends on the goal of the standardization - collecting diverse phenotypic data on most available strains by a few expert investigators (the gold standard) or refining behavioural tests in order to establish a normal range of behaviour that can be used to judge a wider range of strains or even an individual mouse.
AB - Rapid advances in biotechnology have created new demands for tests of mouse behaviour having both high reliability and high throughput for mass screening. This paper discusses several statistical and psychological factors pertinent to replication of results in different laboratories, and it considers the question of which inbred strains are best for test standardization. In this context, the problem of absent corpus callosum in the 129 strains is addressed with data from a recent study of six diverse tests of behaviour, and it is shown that effects of absent corpus callosum are usually nonsignificant and/or very small. Whether any 129 substrain is to be included in the list of standard strains depends on the goal of the standardization - collecting diverse phenotypic data on most available strains by a few expert investigators (the gold standard) or refining behavioural tests in order to establish a normal range of behaviour that can be used to judge a wider range of strains or even an individual mouse.
KW - Anxiety
KW - Gene-environment interaction
KW - Hippocampal commissure
KW - Inbred strains
KW - Locomotor activity
KW - Serotonin receptor knockout
KW - Test standardization
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U2 - 10.1016/S0166-4328(01)00283-2
DO - 10.1016/S0166-4328(01)00283-2
M3 - Article
C2 - 11682089
AN - SCOPUS:0035829371
SN - 0166-4328
VL - 125
SP - 23
EP - 32
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1-2
ER -