Behavioral stress decreases plasma oxytocin concentrations in primates

Ned H. Kalin; Daniel M. Gibbs; Charles M. Barksdale; Steven E. Shelton; Molly Carnes

doi:10.1016/0024-3205(85)90272-3

Behavioral stress decreases plasma oxytocin concentrations in primates

Ned H. Kalin, Daniel M. Gibbs, Charles M. Barksdale, Steven E. Shelton, Molly Carnes

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Using rhesus monkeys, we studied the effects of a behavioral stress on plasma concentrations of adrenocorticotropin, oxytocin, and vasopressin. The stress resulted in significant increases in adrenocorticotropin and significant decreases in oxytocin concentrations. No significant changes were seen in vasopressin concentrations. To further explore the relationship between plasma oxytocin and pituitary-adrenal function, dexamethasone was administered to rhesus monkeys. This resulted in significant increases in plasma oxytocin concentrations, while adrenocorticotropin decreased.

Original language	English (US)
Pages (from-to)	1275-1280
Number of pages	6
Journal	Life Sciences
Volume	36
Issue number	13
DOIs	https://doi.org/10.1016/0024-3205(85)90272-3
State	Published - Apr 1 1985
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(85)90272-3

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title = "Behavioral stress decreases plasma oxytocin concentrations in primates",

abstract = "Using rhesus monkeys, we studied the effects of a behavioral stress on plasma concentrations of adrenocorticotropin, oxytocin, and vasopressin. The stress resulted in significant increases in adrenocorticotropin and significant decreases in oxytocin concentrations. No significant changes were seen in vasopressin concentrations. To further explore the relationship between plasma oxytocin and pituitary-adrenal function, dexamethasone was administered to rhesus monkeys. This resulted in significant increases in plasma oxytocin concentrations, while adrenocorticotropin decreased.",

author = "Kalin, {Ned H.} and Gibbs, {Daniel M.} and Barksdale, {Charles M.} and Shelton, {Steven E.} and Molly Carnes",

note = "Funding Information: This research was supportedb y the Veterans Administration,b y PHS grants NS-18867-01a nd AM-32517-01( to DMG) and by the Stetler Foundation. The authors gratefully acknowledgeth e gift of ACTH standard from Salvatore Raiti of the National Pituitary Agency.",

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doi = "10.1016/0024-3205(85)90272-3",

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T1 - Behavioral stress decreases plasma oxytocin concentrations in primates

AU - Kalin, Ned H.

AU - Gibbs, Daniel M.

AU - Barksdale, Charles M.

AU - Shelton, Steven E.

AU - Carnes, Molly

N1 - Funding Information: This research was supportedb y the Veterans Administration,b y PHS grants NS-18867-01a nd AM-32517-01( to DMG) and by the Stetler Foundation. The authors gratefully acknowledgeth e gift of ACTH standard from Salvatore Raiti of the National Pituitary Agency.

PY - 1985/4/1

Y1 - 1985/4/1

N2 - Using rhesus monkeys, we studied the effects of a behavioral stress on plasma concentrations of adrenocorticotropin, oxytocin, and vasopressin. The stress resulted in significant increases in adrenocorticotropin and significant decreases in oxytocin concentrations. No significant changes were seen in vasopressin concentrations. To further explore the relationship between plasma oxytocin and pituitary-adrenal function, dexamethasone was administered to rhesus monkeys. This resulted in significant increases in plasma oxytocin concentrations, while adrenocorticotropin decreased.

AB - Using rhesus monkeys, we studied the effects of a behavioral stress on plasma concentrations of adrenocorticotropin, oxytocin, and vasopressin. The stress resulted in significant increases in adrenocorticotropin and significant decreases in oxytocin concentrations. No significant changes were seen in vasopressin concentrations. To further explore the relationship between plasma oxytocin and pituitary-adrenal function, dexamethasone was administered to rhesus monkeys. This resulted in significant increases in plasma oxytocin concentrations, while adrenocorticotropin decreased.

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Behavioral stress decreases plasma oxytocin concentrations in primates

Abstract

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