Behavioral responses to amphetamines in identical twins

John Jr Crabbe, L. F. Jarvik, E. H. Liston, D. J. Jenden

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Male, monozygotic twins (six pairs) were repeatedly tested before and after d-amphetamine, I-amphetamine, or placebo administration. Drug effects on cognitive, psychomotor, personality, mood, and pain variables were assessed. Members of a twin pair tended to respond similarly on several tests under placebo conditions, indicating genetic determination of the behavioral variables. In addition, cotwins tended to show similar responses to amphetamine as measured by one test of cognitive function, by several mood and personality variables (hostility, autonomic arousal, friendliness, feelings of tension and loss of control), and tended to have similar plasma levels of both amphetamine isomers. Although shared environmental effects cannot be ruled out, the results are consistent with genetic mediation of a variety of behavioral effects of amphetamines.

Original languageEnglish (US)
Pages (from-to)139-149
Number of pages11
JournalActa Geneticae Medicae et Gemellologiae
Volume32
Issue number2
StatePublished - 1983
Externally publishedYes

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Amphetamines
Monozygotic Twins
Amphetamine
Personality
Placebos
Behavioral Genetics
Dextroamphetamine
Hostility
Arousal
Cognition
Emotions
Pain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Crabbe, J. J., Jarvik, L. F., Liston, E. H., & Jenden, D. J. (1983). Behavioral responses to amphetamines in identical twins. Acta Geneticae Medicae et Gemellologiae, 32(2), 139-149.

Behavioral responses to amphetamines in identical twins. / Crabbe, John Jr; Jarvik, L. F.; Liston, E. H.; Jenden, D. J.

In: Acta Geneticae Medicae et Gemellologiae, Vol. 32, No. 2, 1983, p. 139-149.

Research output: Contribution to journalArticle

Crabbe, JJ, Jarvik, LF, Liston, EH & Jenden, DJ 1983, 'Behavioral responses to amphetamines in identical twins', Acta Geneticae Medicae et Gemellologiae, vol. 32, no. 2, pp. 139-149.
Crabbe, John Jr ; Jarvik, L. F. ; Liston, E. H. ; Jenden, D. J. / Behavioral responses to amphetamines in identical twins. In: Acta Geneticae Medicae et Gemellologiae. 1983 ; Vol. 32, No. 2. pp. 139-149.
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