Behavioral differences between C57BL/6J × FVB/NJ and C57BL/6J × NZB/B1NJ F1 hybrid mice: Relation to control of ethanol intake

A. R. Ozburn, R. A. Harris, Y. A. Blednov

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

C57BL/6J × FVB/NJ F1 (B6 × FVB) mice consume more alcohol than C57BL/6J × NZB/B1NJ F1 (B6 × NZB) mice and this high alcohol consumption is stable after abstinence whereas B6 × NZB show reduced consumption, thus providing models of Sustained Alcohol Preference (SAP) and Reduced Alcohol Preference (RAP). In female hybrids, we assessed several behavioral responses to define behaviors which might predict SAP and RAP. B6 × FVB exhibited less severe ethanol-induced conditioned taste aversion and were less sensitive to ethanol- induced loss of righting reflex than B6 × NZB. Both hybrids demonstrated ethanol-induced place preference and a low ethanol withdrawal severity. We found that these hybrids differ in their sensitivity to the aversive and sedative, but not rewarding, effects of ethanol. Results of elevated plus maze, mirror chamber, and locomotor tests reveal B6 × FVB mice are less anxious and more active than B6 × NZB mice. Results obtained offer insights about factors that determine SAP and RAP in these new genetic models of alcohol consumption.

Original languageEnglish (US)
Pages (from-to)551-563
Number of pages13
JournalBehavior genetics
Volume40
Issue number4
DOIs
StatePublished - Jul 1 2010

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Keywords

  • Alcohol preference or consumption
  • Conditioned place preference
  • Conditioned taste aversion
  • Hybrid
  • Loss of righting reflex

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

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