Behavioral and cardiovascular effects of intravenous methylphenidate in normal subjects and cocaine abusers

Gene Jack Wang, Nora D. Volkow, Robert Hitzemann, Christopher Wong, Burton Angrist, Gail Burr, Kathy Pascani, Naomi Pappas, Angela Lu, Thomas Cooper, Jeffrey A. Lieberman

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

This study compares the behavioral and cardiovascular response to methylphenidate (0.5 mg i.v.) in 10 cocaine abusers and 20 controls. Methylphenidate induced a long-lasting increase in blood pressure and pulse rate in both groups of subjects. It also induced a short-lasting 'high' (27 min) and longer-lasting 'restlessness' (67 min). In the normal subjects, but not in the cocaine abusers, methylphenidate significantly increased sexual desire and induced a subjective experience of 'loss of control'. In the cocaine abusers, methylphenidate consistently induced cocaine craving. While 90% of the cocaine abusers reported methylphenidate as pleasurable, only 50% of the normal subjects did. Cocaine abusers reported that the 'high' induced by methylphenidate was similar to that of cocaine but lasted longer and was associated with more physical effects.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalEuropean Addiction Research
Volume3
Issue number1
StatePublished - Feb 1997
Externally publishedYes

Fingerprint

Methylphenidate
Cocaine
Psychomotor Agitation
experience
Group
Heart Rate
Blood Pressure

Keywords

  • Behavior
  • Cardiovascular effect
  • Cocaine
  • Methylphenidate

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Wang, G. J., Volkow, N. D., Hitzemann, R., Wong, C., Angrist, B., Burr, G., ... Lieberman, J. A. (1997). Behavioral and cardiovascular effects of intravenous methylphenidate in normal subjects and cocaine abusers. European Addiction Research, 3(1), 49-54.

Behavioral and cardiovascular effects of intravenous methylphenidate in normal subjects and cocaine abusers. / Wang, Gene Jack; Volkow, Nora D.; Hitzemann, Robert; Wong, Christopher; Angrist, Burton; Burr, Gail; Pascani, Kathy; Pappas, Naomi; Lu, Angela; Cooper, Thomas; Lieberman, Jeffrey A.

In: European Addiction Research, Vol. 3, No. 1, 02.1997, p. 49-54.

Research output: Contribution to journalArticle

Wang, GJ, Volkow, ND, Hitzemann, R, Wong, C, Angrist, B, Burr, G, Pascani, K, Pappas, N, Lu, A, Cooper, T & Lieberman, JA 1997, 'Behavioral and cardiovascular effects of intravenous methylphenidate in normal subjects and cocaine abusers', European Addiction Research, vol. 3, no. 1, pp. 49-54.
Wang, Gene Jack ; Volkow, Nora D. ; Hitzemann, Robert ; Wong, Christopher ; Angrist, Burton ; Burr, Gail ; Pascani, Kathy ; Pappas, Naomi ; Lu, Angela ; Cooper, Thomas ; Lieberman, Jeffrey A. / Behavioral and cardiovascular effects of intravenous methylphenidate in normal subjects and cocaine abusers. In: European Addiction Research. 1997 ; Vol. 3, No. 1. pp. 49-54.
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