Behavior genetic analyses of drug withdrawal.

John Jr Crabbe, John Belknap

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Many studies with rodent models have illustrated the role of genetic factors in determining the severity of ethanol withdrawal. In studies using inbred mouse strains and mice selectively bred for drug sensitivity, a consistent finding has been that genotypes susceptible to alcohol withdrawal are also susceptible to withdrawal from other drugs with CNS depressant effects. A new method for rough genetic mapping of genes associated with withdrawal, quantitative trait loci (QTL) gene mapping, has recently been employed in the BXD RI recombinant inbred mouse series. Several QTLs are associated with alcohol withdrawal: One such QTL on Chromosome 1 is described. An area of Chromosome 2 contains a QTL marker for a gene affecting withdrawal from acute and chronic ethanol, nitrous oxide, and high-pressure neurological syndrome Type I clonic convulsions.

Original languageEnglish (US)
Pages (from-to)477-482
Number of pages6
JournalAlcohol and alcoholism (Oxford, Oxfordshire). Supplement
Volume2
StatePublished - 1993
Externally publishedYes

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Quantitative Trait Loci
Chromosome Mapping
High Pressure Neurological Syndrome
Ethanol
Alcohols
Central Nervous System Depressants
Pharmaceutical Preparations
Inbred Strains Mice
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 1
Nitrous Oxide
Rodentia
Seizures
Genotype
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Behavior genetic analyses of drug withdrawal. / Crabbe, John Jr; Belknap, John.

In: Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, Vol. 2, 1993, p. 477-482.

Research output: Contribution to journalArticle

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