Beat-to-beat determinants of the beat-to-beat temporal and spatial variability of repolarization

Albert Feeny, Larisa Tereshchenko

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    Abstract

    Background: The goal of this study was to compare the time series predictors of beat-to-beat variability in repolarization in healthy individuals. Methods: Spatial QRS- and T-vector amplitudes, spatial QRS-T, RR' and TT' angles, RR' and QT intervals, and QRS- and T-loop roundness were measured on 453 consecutive sinus beats in 168 healthy subjects (mean age 39.8. ±. 15.6. years; 50% men; 93% white). Panel time-series regression models were adjusted by age, sex, and race. Appropriate time series of ECG metrics served as predictors and outcomes. Results: Increase in T-loop roundness index by 0.1 was associated with 1.1° (95%CI 0.9-2.2; P = 0.048) increase in corresponding TT' angle. One unit increase in a respiration index was associated with 4. ms (95%CI 0.6-7.0; P = 0.021) increase in QT interval. Conclusions: Spatial TT' angle and beat-to-beat variability in T-loop roundness represent intrinsic measures of repolarization variability. QT interval variability characterizes the effect of respiration and heart rate variability.

    Original languageEnglish (US)
    JournalJournal of Electrocardiology
    DOIs
    Publication statusAccepted/In press - 2016

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    Keywords

    • QT interval
    • Repolarization
    • Repolarization variability
    • Spatial TT' angle

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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