Beat-to-beat determinants of the beat-to-beat temporal and spatial variability of repolarization

Albert Feeny, Larisa Tereshchenko

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Background: The goal of this study was to compare the time series predictors of beat-to-beat variability in repolarization in healthy individuals. Methods: Spatial QRS- and T-vector amplitudes, spatial QRS-T, RR' and TT' angles, RR' and QT intervals, and QRS- and T-loop roundness were measured on 453 consecutive sinus beats in 168 healthy subjects (mean age 39.8. ±. 15.6. years; 50% men; 93% white). Panel time-series regression models were adjusted by age, sex, and race. Appropriate time series of ECG metrics served as predictors and outcomes. Results: Increase in T-loop roundness index by 0.1 was associated with 1.1° (95%CI 0.9-2.2; P = 0.048) increase in corresponding TT' angle. One unit increase in a respiration index was associated with 4. ms (95%CI 0.6-7.0; P = 0.021) increase in QT interval. Conclusions: Spatial TT' angle and beat-to-beat variability in T-loop roundness represent intrinsic measures of repolarization variability. QT interval variability characterizes the effect of respiration and heart rate variability.

    Original languageEnglish (US)
    JournalJournal of Electrocardiology
    DOIs
    StateAccepted/In press - 2016

    Fingerprint

    Respiratory Rate
    Healthy Volunteers
    Electrocardiography
    Respiration
    Heart Rate

    Keywords

    • QT interval
    • Repolarization
    • Repolarization variability
    • Spatial TT' angle

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    @article{1d0701703df445caa4dd89abc719c788,
    title = "Beat-to-beat determinants of the beat-to-beat temporal and spatial variability of repolarization",
    abstract = "Background: The goal of this study was to compare the time series predictors of beat-to-beat variability in repolarization in healthy individuals. Methods: Spatial QRS- and T-vector amplitudes, spatial QRS-T, RR' and TT' angles, RR' and QT intervals, and QRS- and T-loop roundness were measured on 453 consecutive sinus beats in 168 healthy subjects (mean age 39.8. ±. 15.6. years; 50{\%} men; 93{\%} white). Panel time-series regression models were adjusted by age, sex, and race. Appropriate time series of ECG metrics served as predictors and outcomes. Results: Increase in T-loop roundness index by 0.1 was associated with 1.1° (95{\%}CI 0.9-2.2; P = 0.048) increase in corresponding TT' angle. One unit increase in a respiration index was associated with 4. ms (95{\%}CI 0.6-7.0; P = 0.021) increase in QT interval. Conclusions: Spatial TT' angle and beat-to-beat variability in T-loop roundness represent intrinsic measures of repolarization variability. QT interval variability characterizes the effect of respiration and heart rate variability.",
    keywords = "QT interval, Repolarization, Repolarization variability, Spatial TT' angle",
    author = "Albert Feeny and Larisa Tereshchenko",
    year = "2016",
    doi = "10.1016/j.jelectrocard.2016.01.007",
    language = "English (US)",
    journal = "Journal of Electrocardiology",
    issn = "0022-0736",
    publisher = "Churchill Livingstone",

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    TY - JOUR

    T1 - Beat-to-beat determinants of the beat-to-beat temporal and spatial variability of repolarization

    AU - Feeny, Albert

    AU - Tereshchenko, Larisa

    PY - 2016

    Y1 - 2016

    N2 - Background: The goal of this study was to compare the time series predictors of beat-to-beat variability in repolarization in healthy individuals. Methods: Spatial QRS- and T-vector amplitudes, spatial QRS-T, RR' and TT' angles, RR' and QT intervals, and QRS- and T-loop roundness were measured on 453 consecutive sinus beats in 168 healthy subjects (mean age 39.8. ±. 15.6. years; 50% men; 93% white). Panel time-series regression models were adjusted by age, sex, and race. Appropriate time series of ECG metrics served as predictors and outcomes. Results: Increase in T-loop roundness index by 0.1 was associated with 1.1° (95%CI 0.9-2.2; P = 0.048) increase in corresponding TT' angle. One unit increase in a respiration index was associated with 4. ms (95%CI 0.6-7.0; P = 0.021) increase in QT interval. Conclusions: Spatial TT' angle and beat-to-beat variability in T-loop roundness represent intrinsic measures of repolarization variability. QT interval variability characterizes the effect of respiration and heart rate variability.

    AB - Background: The goal of this study was to compare the time series predictors of beat-to-beat variability in repolarization in healthy individuals. Methods: Spatial QRS- and T-vector amplitudes, spatial QRS-T, RR' and TT' angles, RR' and QT intervals, and QRS- and T-loop roundness were measured on 453 consecutive sinus beats in 168 healthy subjects (mean age 39.8. ±. 15.6. years; 50% men; 93% white). Panel time-series regression models were adjusted by age, sex, and race. Appropriate time series of ECG metrics served as predictors and outcomes. Results: Increase in T-loop roundness index by 0.1 was associated with 1.1° (95%CI 0.9-2.2; P = 0.048) increase in corresponding TT' angle. One unit increase in a respiration index was associated with 4. ms (95%CI 0.6-7.0; P = 0.021) increase in QT interval. Conclusions: Spatial TT' angle and beat-to-beat variability in T-loop roundness represent intrinsic measures of repolarization variability. QT interval variability characterizes the effect of respiration and heart rate variability.

    KW - QT interval

    KW - Repolarization

    KW - Repolarization variability

    KW - Spatial TT' angle

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