BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells

Manfred Neumann; Annette Wilisch; Bei Cong Ma; Brian J. Druker; Edgar Serfling; B. Robert Franza

BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells

Manfred Neumann, Annette Wilisch, Bei Cong Ma, Brian J. Druker, Edgar Serfling, B. Robert Franza

Knight Cancer Institute

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A human myeloid cell line, Mo7, and a daughter cell line expressing the bcr/abl oncogene, Mo7-P210, were used in a comparative study analyzing the effects of p210(BCR/ABL) expression on tyrosine phosphorylation, specific DNA binding and expression of the proto-oncoprotein c-Rel. The steady state expression of c-Rel was indistinguishable in both cell lines. Tyrosine phosphorylation and DNA binding of c-Rel were slightly elevated in Mo7-P210 cells. Further, Mo7 and Mo7-P210 cells showed different responses concerning c-Rel after stimulation with cytokines and retinoic acid. The results presented here demonstrate that c-Rel can be modulated by hematopoietic cytokines and suggest that bcr/abl expression has an impact on these responses and that c-Rel may be a downstream effector for p210(BCR/ABL).

Original language	English (US)
Pages (from-to)	1075-1083
Number of pages	9
Journal	Anticancer research
Volume	16
Issue number	3 A
State	Published - May 1996

Keywords

BCR/ABL
Chronic myelogenous leukemia (CML)
Cytokines
Retinoic acid
c-Rel

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells",

abstract = "A human myeloid cell line, Mo7, and a daughter cell line expressing the bcr/abl oncogene, Mo7-P210, were used in a comparative study analyzing the effects of p210(BCR/ABL) expression on tyrosine phosphorylation, specific DNA binding and expression of the proto-oncoprotein c-Rel. The steady state expression of c-Rel was indistinguishable in both cell lines. Tyrosine phosphorylation and DNA binding of c-Rel were slightly elevated in Mo7-P210 cells. Further, Mo7 and Mo7-P210 cells showed different responses concerning c-Rel after stimulation with cytokines and retinoic acid. The results presented here demonstrate that c-Rel can be modulated by hematopoietic cytokines and suggest that bcr/abl expression has an impact on these responses and that c-Rel may be a downstream effector for p210(BCR/ABL).",

keywords = "BCR/ABL, Chronic myelogenous leukemia (CML), Cytokines, Retinoic acid, c-Rel",

author = "Manfred Neumann and Annette Wilisch and Ma, {Bei Cong} and Druker, {Brian J.} and Edgar Serfling and Franza, {B. Robert}",

year = "1996",

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TY - JOUR

T1 - BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells

AU - Neumann, Manfred

AU - Wilisch, Annette

AU - Ma, Bei Cong

AU - Druker, Brian J.

AU - Serfling, Edgar

AU - Franza, B. Robert

PY - 1996/5

Y1 - 1996/5

N2 - A human myeloid cell line, Mo7, and a daughter cell line expressing the bcr/abl oncogene, Mo7-P210, were used in a comparative study analyzing the effects of p210(BCR/ABL) expression on tyrosine phosphorylation, specific DNA binding and expression of the proto-oncoprotein c-Rel. The steady state expression of c-Rel was indistinguishable in both cell lines. Tyrosine phosphorylation and DNA binding of c-Rel were slightly elevated in Mo7-P210 cells. Further, Mo7 and Mo7-P210 cells showed different responses concerning c-Rel after stimulation with cytokines and retinoic acid. The results presented here demonstrate that c-Rel can be modulated by hematopoietic cytokines and suggest that bcr/abl expression has an impact on these responses and that c-Rel may be a downstream effector for p210(BCR/ABL).

AB - A human myeloid cell line, Mo7, and a daughter cell line expressing the bcr/abl oncogene, Mo7-P210, were used in a comparative study analyzing the effects of p210(BCR/ABL) expression on tyrosine phosphorylation, specific DNA binding and expression of the proto-oncoprotein c-Rel. The steady state expression of c-Rel was indistinguishable in both cell lines. Tyrosine phosphorylation and DNA binding of c-Rel were slightly elevated in Mo7-P210 cells. Further, Mo7 and Mo7-P210 cells showed different responses concerning c-Rel after stimulation with cytokines and retinoic acid. The results presented here demonstrate that c-Rel can be modulated by hematopoietic cytokines and suggest that bcr/abl expression has an impact on these responses and that c-Rel may be a downstream effector for p210(BCR/ABL).

KW - BCR/ABL

KW - Chronic myelogenous leukemia (CML)

KW - Cytokines

KW - Retinoic acid

KW - c-Rel

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SN - 0250-7005

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JO - Anticancer research

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IS - 3 A

ER -

BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells

Abstract

Keywords

ASJC Scopus subject areas

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