BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells

Manfred Neumann, Annette Wilisch, Bei Cong Ma, Brian J. Druker, Edgar Serfling, B. Robert Franza

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A human myeloid cell line, Mo7, and a daughter cell line expressing the bcr/abl oncogene, Mo7-P210, were used in a comparative study analyzing the effects of p210(BCR/ABL) expression on tyrosine phosphorylation, specific DNA binding and expression of the proto-oncoprotein c-Rel. The steady state expression of c-Rel was indistinguishable in both cell lines. Tyrosine phosphorylation and DNA binding of c-Rel were slightly elevated in Mo7-P210 cells. Further, Mo7 and Mo7-P210 cells showed different responses concerning c-Rel after stimulation with cytokines and retinoic acid. The results presented here demonstrate that c-Rel can be modulated by hematopoietic cytokines and suggest that bcr/abl expression has an impact on these responses and that c-Rel may be a downstream effector for p210(BCR/ABL).

Original languageEnglish (US)
Pages (from-to)1075-1083
Number of pages9
JournalAnticancer research
Volume16
Issue number3 A
StatePublished - May 1 1996

Keywords

  • BCR/ABL
  • Chronic myelogenous leukemia (CML)
  • Cytokines
  • Retinoic acid
  • c-Rel

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Neumann, M., Wilisch, A., Ma, B. C., Druker, B. J., Serfling, E., & Franza, B. R. (1996). BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells. Anticancer research, 16(3 A), 1075-1083.