BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells

Manfred Neumann, Annette Wilisch, Bei Cong Ma, Brian Druker, Edgar Serfling, B. Robert Franza

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A human myeloid cell line, Mo7, and a daughter cell line expressing the bcr/abl oncogene, Mo7-P210, were used in a comparative study analyzing the effects of p210(BCR/ABL) expression on tyrosine phosphorylation, specific DNA binding and expression of the proto-oncoprotein c-Rel. The steady state expression of c-Rel was indistinguishable in both cell lines. Tyrosine phosphorylation and DNA binding of c-Rel were slightly elevated in Mo7-P210 cells. Further, Mo7 and Mo7-P210 cells showed different responses concerning c-Rel after stimulation with cytokines and retinoic acid. The results presented here demonstrate that c-Rel can be modulated by hematopoietic cytokines and suggest that bcr/abl expression has an impact on these responses and that c-Rel may be a downstream effector for p210(BCR/ABL).

Original languageEnglish (US)
Pages (from-to)1075-1083
Number of pages9
JournalAnticancer Research
Volume16
Issue number3 A
StatePublished - May 1996

Fingerprint

Myeloid Cells
Tretinoin
Cytokines
Cell Line
Tyrosine
abl Genes
Phosphorylation
Oncogene Proteins
DNA

Keywords

  • BCR/ABL
  • c-Rel
  • Chronic myelogenous leukemia (CML)
  • Cytokines
  • Retinoic acid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Neumann, M., Wilisch, A., Ma, B. C., Druker, B., Serfling, E., & Franza, B. R. (1996). BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells. Anticancer Research, 16(3 A), 1075-1083.

BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells. / Neumann, Manfred; Wilisch, Annette; Ma, Bei Cong; Druker, Brian; Serfling, Edgar; Franza, B. Robert.

In: Anticancer Research, Vol. 16, No. 3 A, 05.1996, p. 1075-1083.

Research output: Contribution to journalArticle

Neumann, M, Wilisch, A, Ma, BC, Druker, B, Serfling, E & Franza, BR 1996, 'BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells', Anticancer Research, vol. 16, no. 3 A, pp. 1075-1083.
Neumann M, Wilisch A, Ma BC, Druker B, Serfling E, Franza BR. BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells. Anticancer Research. 1996 May;16(3 A):1075-1083.
Neumann, Manfred ; Wilisch, Annette ; Ma, Bei Cong ; Druker, Brian ; Serfling, Edgar ; Franza, B. Robert. / BCR/ABL modulates the cytokine and retinoic acid response of c-Rel in human myeloid cells. In: Anticancer Research. 1996 ; Vol. 16, No. 3 A. pp. 1075-1083.
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AU - Franza, B. Robert

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