Basophil or IgE-Bearing Lymphocyte?

James T. Rosenbaum

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: In an increasing number of experimental protocols, including at least three published in the Journal,1 2 3 investigators have used a specific, fluorescein-conjugated, anti-immunoglobulin to enumerate lymphocytes bearing IgE. Studies on various diseases, including chronic lymphatic leukemia,1,2,4 lepromatous leprosy,3 infantile, X-linked agammaglobulinemia5 and eczema,6 have generally found IgE on 0 to 5 per cent of all peripheral lymphocytes in patients as well as controls. Unless, however, a method was available for distinguishing basophils from lymphocytes after fluorescein staining, this count could be falsely high. None of these studies allude to this possible pitfall. Although all the authors do. No extract is available for articles shorter than 400 words.

Original languageEnglish (US)
Pages (from-to)678-679
Number of pages2
JournalNew England Journal of Medicine
Issue number13
StatePublished - Sep 26 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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